Small Molecule Natural Products and Alzheimer's Disease.
Small Molecule Natural Products and Alzheimer's Disease.
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DOI：
10.2174/1568026619666190201153257
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发表时间：
2019
影响因子：
3.4
通讯作者：
Xiaoai Wu;H. Cai;Lili Pan;Gang Cui;Feng Qin;Yunchun Li;Zhengxin Cai
中科院分区：
文献类型：
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作者：
Xiaoai Wu;H. Cai;Lili Pan;Gang Cui;Feng Qin;Yunchun Li;Zhengxin Cai
阿尔茨海默病（Alzheimer's disease，AD）是一种以记忆丧失、认知障碍和痴呆为特征的进行性、致死性神经退行性疾病。在过去的几十年里，人们根据AD患者脑内的病理变化提出了几种发病机制假说。不幸的是，目前还没有有效的药物/疗法来预防或控制AD。目前，只有少数药物，其功能作为乙酰胆碱酯酶（AChE）抑制剂或N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，可用于缓解症状。由于许多小分子天然产物在中枢神经系统（CNS）药物的开发中显示出其作为受体激动剂或拮抗剂以及脑中酶和蛋白质的抑制剂的功能，因此天然产物很可能在抗AD药物开发中发挥重要作用。我们回顾了最近的论文使用小分子天然产物作为候选药物治疗AD。这些天然产物具有抗氧化、抗炎、抗胆碱酯酶、抗淀粉样蛋白生成和神经保护活性。此外，还对拟用于预防AD、减轻AD症状的生物活性天然产物以及治疗AD的新靶点进行了综述。
Alzheimer's disease (AD) is a progressive and deadly neurodegenerative disease that is characterized by memory loss, cognitive impairment and dementia. Several hypotheses have been proposed for the pathogenesis based on the pathological changes in the brain of AD patients during the last few decades. Unfortunately, there is no effective agents/therapies to prevent or control AD at present. Currently, only a few drugs, which function as acetylcholinesterase (AChE) inhibitors or N-methyl-Daspartate (NMDA) receptor antagonists, are available to alleviate symptoms. Since many small molecule natural products have shown their functions as agonists or antagonists of receptors, as well as inhibitors of enzymes and proteins in the brain during the development of central nervous system (CNS) drugs, it is likely that natural products will play an important role in anti-AD drug development. We review recent papers on using small molecule natural products as drug candidates for the treatment of AD. These natural products possess antioxidant, anti-inflammatory, anticholinesterase, anti-amyloidogenic and neuroprotective activities. Moreover, bioactive natural products intended to be used for preventing AD, reducing the symptoms of AD and the new targets for treatment of AD are summarized.