CHLORINATED-HYDROCARBON LEVELS IN HUMAN-SERUM - EFFECTS OF FASTING AND FEEDING
CHLORINATED-HYDROCARBON LEVELS IN HUMAN-SERUM - EFFECTS OF FASTING AND FEEDING
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DOI：
10.1007/bf01055015
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发表时间：
1989-07-01
影响因子：
4
通讯作者：
NEEDHAM, LL
中科院分区：
文献类型：
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作者：
PHILLIPS, DL;PIRKLE, JL;NEEDHAM, LL
20名健康成年人在24小时内的四个时间点抽取血清样品：禁食12小时后，高脂肪早餐后4-5小时，下午三点左右，以及禁食12小时后的第二天早上。非空腹样本的平均浓度高出22%至29%（p < 0.05）高于空腹样本（多氯联苯，4.81与3.74纳克/克血清重量），六氯苯（六氯苯，0.163对0.134纳克/克血清重量），和p，p“-二氯二苯基二氯乙烯（p，p“-DDE，6.74 ng/g血清重量vs 5.37 ng/g血清重量），通过电子捕获气液色谱法测定。通过测量总胆固醇、游离胆固醇、甘油三酯和磷脂估计血清总脂质，非空腹样本比空腹样本高20%，非空腹样本无统计学差异。由于采用不同的样本采集方案所观察到的氯化烃浓度存在差异，因此需要采用标准化的采集程序或通过血清总脂质水平进行校正，才能对分析结果进行有意义的比较。
Twenty healthy adult humans had serum samples drawn on four occasions within a 24-hr period: after a 12 hr overnight fast, 4-5 hr after a high fat breakfast, at midafternoon, and the next morning after another 12 hr fast. Nonfasting samples had 22% to 29% higher mean concentrations (p < 0.05) than did fasting samples for polychlorinated biphenyls (PCBs, 4.81 vs 3.74 ng/g serum wt), hexachlorobenzene (HCB, 0.163 vs 0.134 ng/g serum wt), and p,p''-dichlorodiphenyldichloroethylene (p,p''-DDE, 6.74 vs 5.37 ng/g serum wt) measured by electron capture gas liquid chromatography. Total serum liids were estimated from measurements of total cholesterol, free cholesterol, triglycerides, and phospholipids and were 20% higher in nonfasting samples than in fasting and non-fasting samples were not statistically different. Because of the differences in the chlorinated hydrocarbon concentrations observed with different sample collection regimens, meaningful comparison of analytical results requires standardized collection procedures or correcting by total serum lipid levels.