Chemical constituents from the branches and leaves of Alchornea annamica
Chemical constituents from the branches and leaves of Alchornea annamica
复制标题
Alchornea annamica 枝叶的化学成分
DOI：
10.1080/14786419.2020.1834552
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发表时间：
2020
影响因子：
2.2
通讯作者：
N. H. Nam
中科院分区：
文献类型：
--
作者：
N. Phan;N. T. Thuan;N. Hien;P. Huyến;T. H. Hanh;T. Quang;N. X. Cuong;N. H. Nam
摘要通过对海南香茶菜枝叶的植物化学研究，分离得到10种次生代谢产物，其中包括两个新的巨替格曼苷alnamicosides A（1）和B（2）。其结构经1D、2D NMR、ECD和HR-QTOF-MS确证。Megastigmane衍生物1 − 3对LPS诱导的RAW 264.7细胞NO生成具有抑制作用，IC 50值分别为78.72 ± 1.90、77.40 ± 9.40和82.16 ± 4.56 µM。这是首次报道该植物的化学成分和生物活性。安娜米卡。图形摘要
Abstract Phytochemical investigation of the branches and leaves of Alchornea annamica led to isolation of ten secondary metabolites, including two new megastigmane glucosides alnamicosides A (1) and B (2). The structure elucidation was confirmed by 1 D and 2 D NMR, ECD as well as HR-QTOF-MS experiments. The megastigmane derivatives 1 − 3 exhibited inhibitory effects on LPS-induced NO production in RAW264.7 cells with IC50 values of 78.72 ± 1.90, 77.40 ± 9.40 and 82.16 ± 4.56 µM, respectively. This is the first report on chemical constituents and biological activity of the plant A. annamica. Graphical Abstract