Models of immune memory:: On the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory
Models of immune memory:: On the role of cross-reactive stimulation, competition, and homeostasis in maintaining immune memory
复制标题
DOI：
10.1073/pnas.95.25.14926
复制
发表时间：
1998-12-08
影响因子：
11.1
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Antia, R;Pilyugin, SS;Ahmed, R
关于抗原持久性、交叉反应刺激、稳态、不同淋巴细胞谱系之间的竞争以及细胞更新率等过程对免疫记忆持续时间和免疫库维持的影响，存在很多争论。我们使用简单的数学模型来研究这些不同过程对免疫记忆寿命（定义为抗原特异性记忆细胞群体的下降率）的贡献。我们开发的模型包含大量免疫细胞，每个谱系都具有不同的抗原特异性，并描述了各个谱系和细胞总数的动态。我们的结果表明，如果稳态控制调节记忆细胞的总数，那么，对于广泛的参数，免疫记忆将在没有持久性抗原的情况下长期存在（T-1/2 > 1 年）。我们还表明，在这种情况下，记忆的寿命对交叉反应刺激的相对速率、免疫细胞的周转率以及维持稳态的功能形式不敏感。
There has been much debate on the contribution of processes such as the persistence of antigens, cross-reactive stimulation, homeostasis, competition between different lineages of lymphocytes, and the rate of cell turnover on the duration of immune memory and the maintenance of the immune repertoire. We use simple mathematical models to investigate the contributions of these various processes to the longevity of immune memory (defined as the rate of decline of the population of antigen-specific memory cells). The models we develop incorporate a large repertoire of immune cells, each lineage having distinct antigenic specificities, and describe the dynamics of the individual lineages and total population of cells. Our results suggest that, if homeostatic control regulates the total population of memory cells, then, for a wide range of parameters, immune memory will be long-lived in the absence of persistent antigen (T-1/2 > 1 year). We also show that the longevity of memory in this situation will be insensitive to the relative rates of cross-reactive stimulation, the rate of turnover of immune cells, and the functional form of the term for the maintenance of homeostasis.