Gender and adolescent alcohol use disorders on bold (blood oxygen level dependent) response to spatial working memory
Gender and adolescent alcohol use disorders on bold (blood oxygen level dependent) response to spatial working memory
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DOI：
10.1093/alcalc/agh134
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发表时间：
2005-05-01
影响因子：
2.8
通讯作者：
Tapert, SF
中科院分区：
文献类型：
--
作者：
Caldwell, LC;Schweinsburg, AD;Tapert, SF
目的：确定饮酒如何不同地影响男性和女性青少年的大脑功能。方法：年龄为 14-17 岁的患有酒精使用障碍的青少年（AUD；7 名女性，11 名男性）和没有 AUD 的对照青少年（9 名女性，12 名男性），在功能磁共振成像期间执行空间工作记忆和警戒任务。结果：性别、AUD 及其相互作用与任务的大脑激活模式显着相关。额叶上区、颞叶上区、扣带回和梭状区存在相互作用，其中患有 AUD 的女性和男性青少年表现出与彼此和对照受试者不同的大脑反应。总体而言，患有 AUD 的女性青少年比患有 AUD 的男性青少年表现出更大的偏离正常激活模式的情况。结论：青少年酒精参与可能对男性和女性大脑产生不同的影响，青少年女性可能更容易受到酒精的不良影响。如果继续饮酒，这些青少年出现行为缺陷的风险可能会增加。
Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents. Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14-17 years, performed spatial working memory and vigilance tasks during functional magnetic resonance imaging. Results: Gender, AUD and their interaction were significantly associated with brain activation patterns to the tasks. There were interactions in the superior frontal, superior temporal, cingulate and fusiform regions, in which female and male adolescents with AUDs showed a different brain response from each other and control subjects. Overall, female adolescents with AUDs showed a greater departure from normal activation patterns than male adolescents with AUD. Conclusions: Adolescent alcohol involvement may affect male and female brains differently, and adolescent females may be somewhat more vulnerable to adverse alcohol effects. With continued drinking, these adolescents may be at an increased risk for behavioural deficits.