Evaluation of the relationship between serum adropin levels and blood pressure in obese children
Evaluation of the relationship between serum adropin levels and blood pressure in obese children
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DOI：
10.1515/jpem-2015-0051
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发表时间：
2015-09-01
影响因子：
1.4
通讯作者：
Sayin, Oya
中科院分区：
文献类型：
--
作者：
Altincik, Ayca;Sayin, Oya
背景：肥胖和相关心血管并发症的患病率正在迅速增加。脂肪因子在肥胖相关炎症和高血压的发病机制中起主要作用。目的：本研究的目的是评估肥胖儿童血清Adropin水平，并确定Adropin水平与儿童年龄组血压（BP）的关系。（平均年龄：12.5 +/-2.5岁;男/女比例：18/22）和15名健康对照（平均年龄：15 +/-3.14岁;男/女比例：5/15）被包括在研究中。比较血清肾上腺素水平以及一些实验室和临床变量。对肥胖受试者进行动态血压监测。Adropin水平和BP变量之间的关系进行了检查。结果：肥胖受试者的血清Adropin水平显著低于健康对照组（193.56 +/- 94 vs. 289 +/- 187 pg/mL，p=0.03）。Adropin水平与体重指数z评分呈负相关（r=-0.56; p=0.034）。肥胖者血清肾上腺素水平与实验室变量无相关性。5例（12.5%）患者为非杓型，9例（22.5%）患者患有高血压。结论：肥胖儿童血清Adropin水平明显降低，但与血压无相关性。需要进一步的研究来确定脂肪因子在BP中的作用。
Background: The prevalence of obesity and related cardiovascular comorbodities is increasing rapidly. Adipokines play a major role in the pathogenesis of obesity-related inflammation and hypertension.Aim: The aim of this study was to evaluate the serum adropin levels in obese children and to determine the relationship between adropin levels and blood pressure (BP) in the pediatric age group.Methods: Forty obese children (mean age: 12.5 +/- 2.5 years; male/female ratio: 18/22) and 15 healthy controls (mean age: 15 +/- 3.14 years; male/female ratio: 5/15) were included in the study. Serum adropin levels, and a number of laboratory and clinical variables were compared. Ambulatory blood pressure monitoring was performed on obese subjects. Relationship between adropin levels and BP variables was examined.Results: Serum adropin levels were significantly lower in obese subjects than in healthy controls (193.56 +/- 94 vs. 289 +/- 187 pg/mL, p=0.03). Adropin levels were correlated negatively with body mass index z-score (r=-0.56; p=0.034). There was no correlation between serum adropin levels and laboratory variables in obese subjects. Five of the patients (12.5%) were nondipper, and nine of the patients (22.5%) had hypertension. There was no significant correlation between serum adropin levels and BP variables.Conclusion: Serum adropin levels were significantly lower in obese children; however, there was no correlation between serum adropin levels and BP variables. Further studies are needed to determine the role of adipokines on BP.