Conserved fMRI and LFP Signals during New Associative Learning in the Human and Macaque Monkey Medial Temporal Lobe
Conserved fMRI and LFP Signals during New Associative Learning in the Human and Macaque Monkey Medial Temporal Lobe
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DOI：
10.1016/j.neuron.2012.03.029
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发表时间：
2012-05-24
期刊：
影响因子：
16.2
通讯作者：
Suzuki, Wendy A.
中科院分区：
文献类型：
--
作者：
Hargreaves, Eric L.;Mattfeld, Aaron T.;Suzuki, Wendy A.
我们在猴子和人类进行相同的条件运动联想学习任务时，分别测量了它们内侧颞叶的局部场电位(LFP)和血氧水平依赖(BOLD)功能磁共振成像(FMRI)。平行分析被用来检查这两个数据集。尽管人类的学习速度比猴子快得多，但我们发现，在两个物种的内嗅觉皮质和海马体中，相同的神经信号可以区分新的刺激和非常熟悉的刺激、第一次刺激呈现、试验结果和学习强度。因此，在猴子和人类身上使用平行的行为任务和分析，揭示了在联想学习任务期间内侧颞叶的神经活动的保守模式。
We measured local field potential (LFP) and blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in the medial temporal lobes of monkeys and humans, respectively, as they performed the same conditional motor associative learning task. Parallel analyses were used to examine both data sets. Despite significantly faster learning in humans relative to monkeys, we found equivalent neural signals differentiating new versus highly familiar stimuli, first stimulus presentation, trial outcome, and learning strength in the entorhinal cortex and hippocampus of both species. Thus, the use of parallel behavioral tasks and analyses in monkeys and humans revealed conserved patterns of neural activity across the medial temporal lobe during an associative learning task.