Mechanisms of glucocorticoid action in bone.
Mechanisms of glucocorticoid action in bone.
复制标题
DOI：
10.1007/s11914-005-0017-7
复制
发表时间：
2005-09-01
影响因子：
4.3
通讯作者：
Canalis, Ernesto
中科院分区：
文献类型：
--
作者：
Canalis, Ernesto
糖皮质激素可引起快速骨丢失，增加骨质疏松性骨折的风险。其机制包括骨吸收增加阶段，可能是核因子-k-B配体和集落刺激因子-1受体激活剂表达增加的结果，随后是骨形成减少。这种作用对于糖皮质激素在骨中的作用至关重要，并且继发于骨形成细胞的损失，这是由细胞分化的抑制和成熟成骨细胞和骨细胞的凋亡增加引起的。糖皮质激素还抑制成熟成骨细胞的功能，并抑制胰岛素样生长因子-I的合成，胰岛素样生长因子-I是一种促进骨形成的药物。糖皮质激素改变软骨中的生长激素/胰岛素样生长因子轴，因此抑制线性生长。
Glucocorticoids induce rapid bone loss and increase the risk for osteoporotic fractures. The mechanisms include a phase of increased bone resorption, probably a result of the increased expression of receptor activator of nuclear factor-k-B ligand and colony stimulating factor-1, followed-up by a decrease in bone formation. This effect is central to the actions of glucocorticoids in bone and it is secondary to the loss of bone forming cells, caused by an inhibition of cell differentiation and an increase in the apoptosis of mature osteoblasts and osteocytes. Glucocorticoids also inhibit the function of mature osteoblasts and suppress the synthesis of insulin-like growth factor-I, an agent that enhances bone formation. Glucocorticoids alter the growth hormone/insulin-like growth factor axis in cartilage and, as a consequence, suppress linear growth.