Polymorphisms of the AURKA (STK15/Aurora kinase) gene and breast cancer risk (United States)
Polymorphisms of the AURKA (STK15/Aurora kinase) gene and breast cancer risk (United States)
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DOI：
10.1007/s10552-005-0429-9
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发表时间：
2006-02-01
影响因子：
2.3
通讯作者：
Hunter, DJ
中科院分区：
文献类型：
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作者：
Cox, DG;Hankinson, SE;Hunter, DJ
AURKA是调节有丝分裂期间G（2）向M转变的重要蛋白质。由于这种调控功能，它被假设为一个潜在的癌症易感基因。在先前的研究中，两种非同义多态性（F31 I和V57 I）与乳腺癌风险相关。我们试图在一项嵌套在前瞻性队列中的大型病例对照研究（护士健康研究）中证实这些发现。31 I和57 V等位基因纯合子的绝经后妇女患浸润性乳腺癌的风险增加（OR 1.63，95%CI 1.08-2.45）。我们还进行了一项荟萃分析，以总结本研究和既往研究中F31 I多态性与乳腺癌风险之间相关性的结果（总结OR 1.29，95% CI 1.08-1.53，p-异质性= 0.29）。这些结果证实了先前的发现，即AURKA代表一个低突变率的乳腺癌易感基因。
AURKA is an important protein in the regulation of G(2) to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous polymorphisms (F31I and V57I) have been associated with breast cancer risk in prior studies. We sought to confirm these findings in a large case control study nested within a prospective cohort, the Nurses' Health Study. Post-menopausal women who were homozygous for the 31I and 57V alleles had an increased risk of invasive breast cancer (OR 1.63, 95% CI 1.08-2.45). We also performed a meta-analysis to summarize the findings of this and prior studies of association between the F31I polymorphism and breast cancer risk (Summary OR 1.29, 95% CI 1.08-1.53, p-heterogeneity = 0.29). These results confirm prior findings that AURKA represents a low penetrance breast cancer susceptibility gene.