Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration
Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration
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DOI：
10.1038/sj.mp.4001038
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发表时间：
2002-01-01
影响因子：
11
通讯作者：
Everall, IP
中科院分区：
文献类型：
--
作者：
Beasley, CL;Cotter, DR;Everall, IP
精神分裂症的神经发育假说表明，这种疾病可能是由于正常的大脑发育中断。虽然被广泛引用，但这方面的神经病理学证据远非决定性的。在额叶和颞叶中，白色神经元的密度和位置的改变已被描述，并导致了异常神经元迁移可能在精神分裂症的病因学中起作用的建议。然而，这些发现并没有被复制。此外，发育异常可能不是精神分裂症所特有的。本研究的目的是使用先进的计算机图像分析技术，检查精神病患者和对照组的白色物质神经元的密度和空间模式分布。在精神分裂症、双相情感障碍、重性抑郁症和匹配对照组（每组n = 15）的额叶中，对微管相关蛋白-2免疫反应的白色神经元进行定量。分析表明，白色神经元的密度和空间分布在对照组和精神病组之间没有显着差异。这项研究不能重复精神分裂症患者白色物质异常的早期发现，也没有发现任何研究疾病中大脑发育异常的证据。
The neurodevelopmental hypothesis of schizophrenia suggests that this disorder may result from a disruption of normal brain development. While widely cited, neuropathological evidence for this is far from conclusive. Alterations in the density and position of white matter neurons have been previously described in the frontal and temporal lobes and have led to suggestions that abnormal neuronal migration may play a role in the aetiology of schizophrenia. However, these findings have not been replicated. Furthermore, developmental abnormalities may not be specific to schizophrenia. The aim of this study was to examine the density and spatial pattern distribution of white matter neurons in psychiatric and control subjects using sophisticated computerised image analysis techniques. White matter neurons immunoreactive for microtubule associated protein-2 were quantified in the frontal lobe in schizophrenia, bipolar disorder, major depressive disorder and matched controls (each group n = 15). Analysis showed that the density and spatial distribution of white matter neurons did not differ significantly between the control and psychiatric groups. This study cannot replicate the earlier findings of white matter abnormalities in schizophrenia and finds no evidence for abnormal brain development in any of the disorders studied.