Palladium-catalyzed cross-coupling reaction of alkenyl bromides with potassium alkyltrifluoroborates
Palladium-catalyzed cross-coupling reaction of alkenyl bromides with potassium alkyltrifluoroborates
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DOI：
10.1016/j.tet.2006.10.088
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发表时间：
2007-01-15
期刊：
影响因子：
2.1
通讯作者：
Seapy, Dave G.
中科院分区：
文献类型：
--
作者：
Molander, Gary A.;Ham, Jungyeob;Seapy, Dave G.
在80℃的甲苯水溶液中，以10 mol %的PdCl2（dppf）中心点CH2Cl2和3.0等量的Cs2CO3存在下，三氟烷基酸钾与各种烯基溴进行了suzuki - miyura型交叉偶联反应，得到了63-95%收率的所需化合物。在碱性条件下，烷基三氟硼酸钾中的多种官能团是可耐受的。(c) 2006 Elsevier Ltd.版权所有。
The Suzuki-Miyaura-type cross-coupling reaction of potassium alkyltrifluoroborates with various alkenyl bromides in the presence of 10 mol % of PdCl2(dppf)center dot CH2Cl2 and 3.0 equiv of Cs2CO3 in aqueous toluene at 80 degrees C provided the desired compounds in 63-95% yields. A variety of functional groups in the potassium alkyltrifluoroborates were tolerated under the basic conditions. (c) 2006 Elsevier Ltd. All rights reserved.