Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation
Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation
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DOI：
10.1073/pnas.1120860109
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发表时间：
2012-04-10
影响因子：
11.1
通讯作者：
Feinberg, Irwin
中科院分区：
文献类型：
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作者：
Campbell, Ian G.;Grimm, Kevin J.;Feinberg, Irwin
青少年非快速眼动 (NREM) 睡眠的慢波（δ，1-4 Hz）脑电图 (EEG) 急剧下降，这是大脑电生理学的一个巨大的成熟变化，被认为是由皮质突触修剪驱动的。一个长期存在的问题是大脑电生理学的这种变化是否与性成熟有关。将 Gompertz 生长模型应用于 9-18 岁的纵向数据，我们发现 Delta 下降的时间与青春期成熟的时间显着相关（P < 0.0001）。当三角洲下降时间的性别差异受到统计控制时，这种时间关系仍然显着。性别差异和与青春期时间的关系共同解释了 67% 受试者间 Delta 下降时间差异。这些数据证明了青春期与青少年大脑发育的电生理标志之间的时间关系。它们可以指导研究青春期的神经内分泌事件是否与皮质成熟有机械联系，或者这两个成熟过程是否是平行但独立的人类本体发生程序。
The steep adolescent decline in the slow wave (delta, 1-4 Hz) electroencephalogram (EEG) of nonrapid eye movement (NREM) sleep is a dramatic maturational change in brain electrophysiology thought to be driven by cortical synaptic pruning. A perennial question is whether this change in brain electrophysiology is related to sexual maturation. Applying Gompertz growth models to longitudinal data spanning ages 9-18 y, we found that the timing of the delta decline was significantly (P < 0.0001) linked to timing of pubertal maturation. This timing relation remained significant when sex differences in the timing of the delta decline were statistically controlled. Sex differences and the relation to the timing of puberty jointly explained 67% of the between-subject variance in the timing of the delta decline. These data provide a demonstration of a temporal relation between puberty and an electrophysiological marker of adolescent brain development. They can guide research into whether the neuroendocrine events of puberty are mechanistically linked to cortical maturation or whether, instead, the two maturational processes are parallel but independent programs of human ontogenesis.