Epigenetic activation of tumor suppressor microRNAs in human cancer cells
Epigenetic activation of tumor suppressor microRNAs in human cancer cells
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DOI：
10.4161/cc.5.19.3340
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发表时间：
2006-10-01
期刊：
影响因子：
4.3
通讯作者：
Jones, Peter A.
中科院分区：
文献类型：
--
作者：
Saito, Yoshimasa;Jones, Peter A.
MicroRNAs （miRNAs）是一种小的非编码rna，其功能是内源性靶基因的转录后沉默子。mirna以组织特异性的方式表达，在动物发育过程中对细胞增殖、凋亡和分化发挥重要作用。最近的研究表明，miRNAs的异常表达与癌症的发展之间存在明显的联系，这表明miRNAs可能是潜在的治疗靶点。我们最近的研究表明，在人类癌细胞中，一些mirna受表观遗传改变（如DNA甲基化和组蛋白修饰）的控制。通过染色质修饰药物激活肿瘤抑制mirna可能导致靶癌基因的下调，可能成为预防和治疗人类癌症的新策略。
MicroRNAs ( miRNAs) are small non-coding RNAs that function as endogenous post-transcriptional silencers of target genes. miRNAs are expressed in a tissue specific manner and play important roles in cell proliferation, apoptosis and differentiation during animal development. Recent studies have shown a distinct connection between aberrant expression of miRNAs and the development of cancer, suggesting that miRNAs can be potential therapeutic targets. Our recent study has shown that some miRNAs are controlled by epigenetic alterations such as DNA methylation and histone modification in human cancer cells. Activation of tumor suppressor miRNAs by chromatin modifying drugs may cause downregulation of target oncogenes and could be a novel strategy for the prevention and treatment of human cancer.