Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
复制标题
用药物阻断恶性疟原虫疟疾传播：当前和未来抗疟药的杀配子体和杀孢子特性
作者：
A. Kiszewski
杀死或抑制疟原虫性阶段的药物可能会通过阻止传播给蚊子来放大或协同其他干预措施的影响。伯氨喹和其他 8-氨基喹啉长期以来一直具有这种潜力，但安全性和其他问题限制了它们的使用。尽管传播阻断特性通常不是药物发现工作的优先事项，但近年来出现了许多有趣的杀配子细胞和/或杀孢子候选药物。有些仍然存在重大的技术和安全问题，而另一些则已经通过了临床试验，即将进入抗疟疾武器库。我们对配子细胞分化、配子发生和孢子生殖知识的最新进展也导致了对可能干扰疟疾传播的药物的大量潜在新靶点的鉴定。本综述探讨了现有和未来药物的特性、作用机制、禁忌症及其在区域疟疾消除工作中的潜在作用。
Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes. Primaquine and other 8-aminoquinolines have long offered such potential, but safety and other concerns have limited their use. Although transmission-blocking properties are not often a priority of drug discovery efforts, a number of interesting gametocytocidal and/or sporontocidal drug candidates have emerged in recent years. Some still bear significant technical and safety concerns, while others have passed clinical trials and are on the verge of entering the antimalarial armamentarium. Recent advances in our knowledge of gametocyte differentiation, gametogenesis and sporogony have also led to the identification of a large array of potential new targets for drugs that might interfere with malaria transmission. This review examines the properties of existing and prospective drugs, mechanisms of action, counter-indications and their potential role in regional malaria elimination efforts.
DOI：
10.1073/pnas.0501858102
发表时间：
2005-11-15
影响因子：
11.1
作者：
Furuya, T;Mu, JB;Su, XZ
通讯作者：
Su, XZ
伯氨喹诱导的溶血性贫血：芳基羟胺代谢物 6-甲氧基-8-羟氨基喹啉的形成和血液毒性。
DOI：
--
发表时间：
2001
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Bolchoz,LJ;Budinsky,RA;McMillan,DC;Jollow,DJ
通讯作者：
Jollow,DJ