Prostate cancer characteristics in a multiracial community
Prostate cancer characteristics in a multiracial community
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DOI：
10.1016/j.eururo.2007.04.048
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发表时间：
2008-03-01
期刊：
影响因子：
23.4
通讯作者：
Boccon-Gibod, Laurent
中科院分区：
文献类型：
--
作者：
Ravery, Vincent;Dominique, Sebastien;Boccon-Gibod, Laurent
Objectives: To investigate the hypothesis that Northern Africans differ from Caucasians with regard to their PCa characteristics, using our 1988-2006 database we retrospectively reviewed the preoperative and pathological features of consecutive patients subjected to radical prostatectomy (RP) for localized prostate cancer (PCa) and stratified according to their ethnic origin.Methods: In 727 consecutive patients (616 Caucasians; 61 Blacks originating from Central Africa and the French West Indies; 50 Northern Africans from Morocco, Algeria, Tunisia), we preoperatively analyzed and compared age, clinical stage of the tumour, prostate-specific antigen (PSA), transrectal ultrasound prostate volume, PSA density (PSAD), biopsy Gleason score, number of positive cores (NPC), and percentage of tissue core invaded by cancer (PTIC); postoperatively, we determined the status of the capsule, seminal vesicles, and margins of the RP specimen, as well as Gleason score and prostate weight. Statistical analyses (chi-square test and ANOVA) were performed to compare the results between the three groups of patients. A multivariate analysis was carried out to test the independence of variables.Results: Black patients were the youngest at the time of surgery (by 3-4 yr) and had the highest rates of final Gleason score >= 8. The Northern Africans had more favourable features than did Caucasian and Black patients: mean PTIC was 7.1% versus 14.6% and 12.5%, respectively (p = 0.005), mean NPC was 26.4% versus 34.7% and 36.4%, respectively (p = 0.034), rates of biopsy and final Gleason score > 8 were significantly lower (p = 0.02 and p = 0.028, respectively), and there were positive margins in 26% versus 36% and 35.6%, respectively (p > 0.05).Conclusions: This study showed that a French Black population is the most likely of those studied to have unfavourable PCa characteristics at the time of RP. Albeit in a limited series, we show for the first time that Northern Africans have significantly better features in this regard than Caucasians and Blacks. Although Northern Africans did not have a better pathological stage outcome, they did have a more favourable Gleason score. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
