Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months
Immune responses to measles and mumps vaccination of infants at 6, 9, and 12 months
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DOI：
10.1086/323346
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发表时间：
2001-10-01
影响因子：
6.4
通讯作者：
Arvin, AM
中科院分区：
文献类型：
--
作者：
Gans, H;Yasukawa, L;Arvin, AM
在最小的年龄为婴儿接种麻疹疫苗有可能降低发病率和死亡率。通过在接种前后测量T细胞增殖、干扰素-γ产生和中和抗体效价来评估6、9或12个月婴儿对麻疹和腮腺炎疫苗的应答能力。所有年龄段的婴儿对麻疹或流行性腮腺炎病毒的细胞免疫反应相同，无论接种时是否有被动抗体。相比之下，没有被动抗体的6个月大的婴儿对麻疹或腮腺炎病毒的抗体几何平均滴度较低，血清转换率也较低。如果婴儿在12个月后重新接种疫苗，麻疹病毒抗体的几何平均滴度会增加。6个月大的婴儿对副粘病毒疫苗的体液反应有限，而细胞免疫与年龄较大的婴儿相同。尽管存在被动抗体，这些减毒活疫苗在第一年仍可通过免疫建立T细胞反应。
Immunizing infants against measles at the youngest age possible has the potential to reduce morbidity and mortality. The ability of infants at 6, 9, or 12 months to respond to measles and mumps vaccines was evaluated by measuring T cell proliferation, interferon-gamma production, and neutralizing antibody titers before and after vaccination. Infants in all age groups had equivalent cellular immune responses to measles or mumps viruses, with or without passive antibodies when immunized. In contrast, 6-month-old infants without passive antibodies had low geometric mean titers of antibody to measles or mumps viruses and low seroconversion rates. Geometric mean titers of antibody to measles virus increased if infants were revaccinated at 12 months. Six-month-old infants had limited humoral responses to paramyxovirus vaccines, whereas cellular immunity was equivalent to that of older infants. T cell responses can be established by immunization with these live attenuated virus vaccines during the first year, despite the presence of passive antibodies.