Marijuana use, diet, body mass index, and cardiovascular risk factors (from the CARDIA Study)
Marijuana use, diet, body mass index, and cardiovascular risk factors (from the CARDIA Study)
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DOI：
10.1016/j.amjcard.2006.03.024
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发表时间：
2006-08-15
影响因子：
2.8
通讯作者：
Sidney, Stephen
中科院分区：
文献类型：
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作者：
Rodondi, Nicolas;Pletcher, Mark James;Sidney, Stephen
马里替尼的使用与食欲增加、高热量饮食、血压急性升高以及高密度脂蛋白胆固醇和甘油三酯降低有关。马兜铃酸是美国最常用的非法药物，但其对身体质量指数（BMI）和心血管风险因素的长期影响尚不清楚。使用来自3，617名参与年轻人冠状动脉风险发展（CARDIA）研究的黑人和白色年轻人的15年纵向数据，我们评估了大麻使用是否与热量摄入，BMI和心血管风险因素相关。在3,617名参与者中，有1,365人（38%）报告曾使用大麻。避孕药的使用与男性、吸烟和其他非法药物的使用有关。更广泛的大麻使用与更高的热量摄入有关（从不使用大麻者每天2，746千卡，15年内使用大麻≥ 1，800天者每天3，365千卡）和酒精摄入量（3.6至10.8杯/周），收缩压（112.7至116.5 mm Hg）和甘油三酯水平（84至100 mg/dl或0.95至1.13 mmol/L，趋势的所有p值< 0.001），但BMI、脂质和葡萄糖水平不较高。在多变量分析中，大麻使用与收缩压和甘油三酯之间的关联消失了，主要是由于大麻使用者中更多的酒精使用而混淆。总之，尽管大麻的使用与心血管风险因素无关，但它与其他不健康的行为有关，如高热量饮食，吸烟和其他非法药物的使用，这些都对健康有长期的有害影响。(c)2006年爱思唯尔公司All rights reserved.
Marijuana use has been associated with increased appetite, high caloric diet, acute increase in blood pressure, and decreases in high-density lipoprotein cholesterol and triglycerides. Marijuana is the most commonly used illicit drug in the United States, but its long-term effects on body mass index (BMI) and cardiovascular risk factors are unknown. Using 15 years of longitudinal data from 3,617 black and white young adults participating in the Coronary Artery Risk Development in Young Adults (CARDIA) study, we assessed whether marijuana use was associated with caloric intake, BMI, and cardiovascular risk factors. Of the 3,617 participants, 1,365 (38%) reported ever using marijuana. Marijuana use was'associated with male gender, tobacco smoking, and other illicit drug use. More extensive marijuana use was associated with a higher caloric intake (2,746 kcal/day in never users to 3,365 kcal/day in those who used marijuana for >= 1,800 days over 15 years) and alcohol intake (3.6 to 10.8 drinks/week), systolic blood pressure (112.7 to 116.5 mm Hg), and triglyceride levels (84 to 100 mg/dl or 0.95 to 1.13 mmol/L, all p values for trend < 0.001), but not with higher BMI and lipid and glucose levels. In multivariate analysis, the associations between marijuana use and systolic blood pressure and triglycerides disappeared, having been mainly confounded by greater alcohol use in marijuana users. In conclusion, although marijuana use was not independently associated with cardiovascular risk factors, it was associated with other unhealthy behaviors, such as high caloric diet, tobacco smoking, and other illicit drug use, which all have long-term detrimental effects on health. (c) 2006 Elsevier Inc. All rights reserved.