Hemolysis of 40% hematocrit, Albunex(R)-supplemented human erythrocytes by pulsed ultrasound: Frequency, acoustic, pressure and pulse length dependence
Hemolysis of 40% hematocrit, Albunex(R)-supplemented human erythrocytes by pulsed ultrasound: Frequency, acoustic, pressure and pulse length dependence
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DOI：
10.1016/s0301-5629(97)00126-9
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发表时间：
1997-01-01
影响因子：
2.9
通讯作者：
Miller, MW
中科院分区：
文献类型：
--
作者：
Brayman, AA;Strickler, PL;Miller, MW
探讨了脉冲超声溶血作用与超声频率、声压和脉冲宽度的关系。（40%红细胞压积;补充自体血浆）暴露于（60秒）频率为1.02，2.24或3.46 MHz和峰值负压[P-]范围为0.0至近似3.0，MPa（增量为0.5 MPa）时，占空因数为0.01。在各频率下，溶血随声压的增加而增加，对脉冲宽度的依赖性较弱。在较高声压下，溶血对超声频率的依赖性较强，在较低声压下，频率依赖性较弱。(C)1997年世界医学和生物学超声联合会。
The dependence of hemolysis produced by pulsed ultrasound on ultrasound frequency, acoustic pressure and pulse length was explored, Human erythrocytes (40% hematocrit; in Albunex(R)-supplemented autologous plasma) were exposed (60 s) to 20 or 200 mu s pulses of ultrasound at frequencies of 1.02, 2.24 or 3.46 MHz and at peak negative pressures [P-] ranging from 0.0 to similar to 3.0, MPa in 0.5 MPa increments, The duty factor was 0.01. At each frequency, hemolysis increased with increasing acoustic pressure and depended weakly on pulse duration, At relatively high acoustic pressures, hemolysis depended strongly on ultrasound frequency; at lower pressures, the frequency dependence was weaker, The potential clinical significance of ultrasonic hemolysis is discussed. (C) 1997 World Federation for Ultrasound in Medicine & Biology.