Hemophagocytic lymphohistiocytosis presenting with thrombocytopenia in the newborn.
Hemophagocytic lymphohistiocytosis presenting with thrombocytopenia in the newborn.
复制标题
新生儿噬血细胞性淋巴组织细胞增多症表现为血小板减少症。
DOI：
10.1097/00043426-200206000-00017
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
S. Jayabose
中科院分区：
文献类型：
--
作者：
O. Levendoglu‐Tugal;M. Ozkaynak;Edmund LaGamma;A. Sherbany;C. Sandoval;S. Jayabose
噬血细胞性淋巴组织细胞增多症（HLH）可能在新生儿时期出现血小板减少症。三个新生儿（一个足月和两个早产儿）提出在新生儿期间与血小板减少症。2例新生儿短暂恢复。在5周和7周血小板减少症复发及临床症状出现后诊断为HLH。第三个婴儿为早产儿，在8天大时表现出HLH的临床和实验室特征。三名新生儿均接受化疗，反应良好。在血液学和临床缓解后，两名新生儿接受了同种异体供体的造血干细胞移植。第三个新生儿目前正在接受化疗。新生儿期原因不明的持续性或复发性血小板减少应引起对HLH的怀疑，即使其他症状或体征尚不明显。
Hemophagocytic lymphohistiocytosis (HLH) may present with thrombocytopenia during the newborn period. Three neonates (one term and two preterm) presented during the newborn period with thrombocytopenia. Transient recovery occurred in two newborns. The diagnosis of HLH was made after the recurrence of thrombocytopenia and the clinical symptoms at 5 and 7 weeks. The third infant was a premature baby diagnosed at 8 days of age after manifesting the clinical and laboratory features of HLH. All three neonates were treated with chemotherapy and responded well. After hematologic and clinical remission was achieved, the two newborns received hematopoietic stem cell transplantation from allogeneic donors. The third neonate is currently receiving chemotherapy. Persistent or recurrent thrombocytopenia of undetermined cause during the neonatal period should raise the suspicion of HLH, even though other symptoms or signs are not yet evident.