The arrangement and functions of the chains of the acetylcholine receptor of Torpedo electric tissue.
The arrangement and functions of the chains of the acetylcholine receptor of Torpedo electric tissue.
复制标题
鱼雷电组织乙酰胆碱受体链的排列和功能。
DOI：
10.1101/sqb.1983.048.01.003
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Holtzman,E
中科院分区：
文献类型：
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作者：
Karlin,A;Cox,R;Kaldany,RR;Lobel,P;Holtzman,E
本文研究了构成烟碱型乙酰胆碱受体(AChR)的五条多肽链。我们已经使用电子显微镜来确定链之间的相对位置。我们还使用亲和标记和时间分辨光标记来确定除ACh结合位点之外的链上的功能位点。这些研究的背景已经被Karlin(1980)、Changeux(1981)以及Conti-Tronconi和Raftery(1982)所回顾。我们的结论是：(1)受体的五条链以A3、A~5和B-链的顺序围绕中轴排列，A-链和B-链对局部麻醉剂的重要结合部位具有重要作用。
This paper is concerned with the five polypeptide chains that constitute the nicotinic acetylcholine receptor (AChR). We have used electron microscopy to locate the chains relative to one another. We have also used affinity labels and time-resolved photolabeling to identify functional sites on the chains other than the ACh-binding sites. The background for these studies has been reviewed by Karlin (1980), Changeux (1981), and Conti-Tronconi and Raftery (1982). Our conclusions are (1) that the five chains of the receptor are arranged around the central axis in the order a3, a~ 5 and (2) that the a-and B-chains contribute to functionally significant local anesthetic binding sites.