COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression
COMPASS, a histone H3 (lysine 4) methyltransferase required for telomeric silencing of gene expression
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DOI：
10.1074/jbc.c200023200
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发表时间：
2002-03-29
影响因子：
4.8
通讯作者：
Shilatifard, A
中科院分区：
文献类型：
--
作者：
Krogan, NJ;Dover, J;Shilatifard, A
trithorax （Trx）蛋白家族在某些生物体中维持特定的基因表达模式是必需的。最近，我们报道了一种包含酵母trx相关蛋白set1的多蛋白复合物COMPASS的分离和鉴定。在这里，我们报道COMPASS在体外催化组蛋白H3的第四赖氨酸甲基化。体内组蛋白H3甲基化和染色体端粒附近基因的转录沉默也需要Setl和COMPASS的其他几个组分。
The trithorax (Trx) family of proteins is required for maintaining a specific pattern of gene expression in some organisms. Recently we reported the isolation and characterization of COMPASS, a multiprotein complex that includes the Trx-related protein Set1of the yeast Saccharomyces cerevisiae. Here we report that COMPASS catalyzes methylation of the fourth lysine of histone H3 in vitro. Setl and several other components of COMPASS are also required for histone H3 methylation in vivo and for transcriptional silencing of a gene located near a chromosome telomere.