Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
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DOI：
10.1152/ajpregu.00397.2003
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发表时间：
2004-06-01
影响因子：
2.8
通讯作者：
Czeisler, CA
中科院分区：
文献类型：
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作者：
Barger, LK;Wright, KP;Czeisler, CA
轮班工人和跨子午线旅行者面临异常的工作-休息周期，导致睡眠-觉醒周期和内源性昼夜节律计时系统之间的相位关系发生变化。昼夜节律错位与睡眠中断以及警觉性和认知能力下降有关。运动已被研究作为促进昼夜节律适应的行为对策。与之前的研究相比，结果可能会受到环境光暴露的影响，本次研究是在严格控制的非常昏暗的光线（类似于 0.65 勒克斯；注视角度）条件下进行的，以尽量减少光的相位重置效应。 18 名健康的年轻男性完成了一项为期 15 天的随机临床试验，在睡眠-觉醒时间表延迟 9 小时后，在进行一周夜间运动或非运动控制条件之前和之后，以恒定的常规测量昼夜节律阶段。每 30 - 60 分钟收集一次血浆样本，分析褪黑激素以确定昼夜节律阶段。与非运动对照组相比，每晚完成 3 轮 45 分钟自行车测功的受试者在弱光褪黑激素起始 (DLMO25%)、弱光褪黑激素偏移和褪黑激素分布中点方面表现出显着更大的变化（学生 t 检验；P < 0.05）。运动干预引起的相位延迟的大小显着取决于干预前 DLMO25% 后运动的相对时间（r = - 0.73，P < 0.05），因此越接近 DLMO25%，相移越大。这些数据表明，锻炼可能有助于促进昼夜节律适应需要延迟睡眠-觉醒周期的时间表。
Shift workers and transmeridian travelers are exposed to abnormal work-rest cycles, inducing a change in the phase relationship between the sleep-wake cycle and the endogenous circadian timing system. Misalignment of circadian phase is associated with sleep disruption and deterioration of alertness and cognitive performance. Exercise has been investigated as a behavioral countermeasure to facilitate circadian adaptation. In contrast to previous studies where results might have been confounded by ambient light exposure, this investigation was conducted under strictly controlled very dim light ( standing similar to 0.65 lux; angle of gaze) conditions to minimize the phase-resetting effects of light. Eighteen young, fit males completed a 15-day randomized clinical trial in which circadian phase was measured in a constant routine before and after exposure to a week of nightly bouts of exercise or a nonexercise control condition after a 9-h delay in the sleep-wake schedule. Plasma samples collected every 30 - 60 min were analyzed for melatonin to determine circadian phase. Subjects who completed three 45-min bouts of cycle ergometry each night showed a significantly greater shift in the dim light melatonin onset (DLMO25%), dim light melatonin offset, and midpoint of the melatonin profile compared with nonexercising controls (Student t-test; P < 0.05). The magnitude of phase delay induced by the exercise intervention was significantly dependent on the relative timing of the exercise after the preintervention DLMO25% (r = - 0.73, P < 0.05) such that the closer to the DLMO25%, the greater the phase shift. These data suggest that exercise may help to facilitate circadian adaptation to schedules requiring a delay in the sleep-wake cycle.