Identification and characterization of SorCS, a third member of a novel receptor family
Identification and characterization of SorCS, a third member of a novel receptor family
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DOI：
10.1006/bbrc.1999.1822
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发表时间：
1999-12-20
影响因子：
3.1
通讯作者：
Hermans-Borgmeyer, I
中科院分区：
文献类型：
--
作者：
Hermey, G;Riedel, IB;Hermans-Borgmeyer, I
从小鼠大脑中分离出一种新的受体，SorCS。它与嵌合受体 SorLA 和神经降压素受体分拣蛋白具有同源性，基于共同的 VPS10 结构域，这是这个新受体家族的标志。在 SorCS 的 N 末端，两个假定的弗林蛋白酶转化酶切割位点标记了 VPS10 结构域的开始，随后是不完美的富含亮氨酸重复序列模块和跨膜结构域。短的细胞内 C 末端包含快速内化的共有信号。已鉴定的 SH2 和 SH3 结构域的推定结合基序在 VPS10 结构域受体家族中是独特的。 SorCS 主要在脑中表达，但也在心脏、肝脏和肾脏中表达。通过原位杂交在小鼠中枢神经系统中检测到的 SorCS 转录物指向神经元表达。 (C) 1999 年学术出版社。
A novel receptor, SorCS, was isolated from murine brain. It shows homology to the mosaic receptor SorLA and the neurotensin receptor sortilin based on a common VPS10 domain which is the hallmark of this new receptor family. In the N-terminus of SorCS two putative cleavage sites for the convertase furin mark the beginning of the VPS10 domain, followed by a module of imperfect leucine-rich repeats and a transmembrane domain. The short intracellular C-terminus contains consensus signals for rapid internalization. The identified putative binding motifs for SH2 and SH3 domains are unique in the family of VPS10 domain receptors. SorCS is predominantly expressed in brain, but also in heart, liver, and kidney. SorCS transcripts detected by in situ hybridization in the murine central nervous system point to a neuronal expression. (C) 1999 Academic Press.