Clonal Hematopoiesis: From Mechanisms to Clinical Intervention.
Clonal Hematopoiesis: From Mechanisms to Clinical Intervention.
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DOI：
10.1158/2159-8290.cd-21-0901
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发表时间：
2021-12-01
期刊：
影响因子：
28.2
通讯作者：
Majeti R
中科院分区：
文献类型：
--
作者：
Köhnke T;Majeti R
在过去的几年里，我们对克隆造血 (CH) 如何与各种健康状况相关的知识有了很大的增长，涉及癌症医学以外的许多专业。鉴于 CH 在许多情况下可能是明显疾病的先兆，早期干预的前景引起了广泛关注。在这篇综述中，我们讨论了 CH 研究的现状，并概述了开展早期干预临床试验的挑战。我们预计 CH 的偶然发现在不久的将来将变得更加常见，但目前缺乏如何管理这些发现的循证努力。
Our knowledge of how clonal hematopoiesis (CH) relates to diverse health conditions has grown vastly over the past years, touching upon many specialties beyond cancer medicine. Given that CH can act as a precursor to overt disease in many settings, the promise of early intervention has garnered much attention. In this review, we discuss the state of CH research and outline the challenges in developing clinical trials of early interventions. We anticipate that incidental findings of CH will become more common in the near future, but evidence-based efforts of how to manage these findings is currently lacking.
影响因子：
20.3
作者：
Bolton KL;Foote M;Jee J;Safonov A;Ptashkin R;Devlin S;Gedvilaite E;Gao T;Papaemmanuil E;Pessin MS;Kamboj M;Vijai J;Offit K;Awadalla P;Nataranjan P;Berger MF;Norton L;Levine RL;Zehir A
通讯作者：
Zehir A