Hypothalamic responses to long-chain fatty acids are nutritionally regulated
Hypothalamic responses to long-chain fatty acids are nutritionally regulated
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DOI：
10.1074/jbc.m400458200
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发表时间：
2004-07-23
影响因子：
4.8
通讯作者：
Rossetti, L
中科院分区：
文献类型：
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作者：
Morgan, K;Obici, S;Rossetti, L
长链脂肪酸油酸的中央给药抑制大鼠的食物摄入和葡萄糖产生。在这里，我们研究了营养可用性的短期变化是否可以调节油酸的这些代谢和行为影响。将大鼠分为三组，接受高度适口的能量密集型饮食，每日热量水平不断增加（低于、相似或高于喂养标准食物的大鼠的平均值）。按照指定的饮食方案三天后，测试了大鼠对第三脑室输注油酸的急性生物反应。三天的过量喂食实际上消除了油酸中枢给药的代谢和厌食作用。此外，在短期过度喂养后，第三脑室输注油酸未能降低下丘脑中神经肽Y的表达和肝脏中葡萄糖-6-磷酸酶的表达。短期过量喂养后下丘脑对油酸缺乏反应可能导致该动物模型体重快速增加和肝脏胰岛素抵抗。
Central administration of the long-chain fatty acid oleic acid inhibits food intake and glucose production in rats. Here we examined whether short term changes in nutrient availability can modulate these metabolic and behavioral effects of oleic acid. Rats were divided in three groups receiving a highly palatable energy-dense diet at increasing daily caloric levels ( below, similar, or above the average of rats fed standard chow). Following 3 days on the assigned diet regimen, rats were tested for acute biological responses to the infusion of oleic acid in the third cerebral ventricle. Three days of overfeeding virtually obliterated the metabolic and anorectic effects of the central administration of oleic acid. Furthermore, the infusion of oleic acid in the third cerebral ventricle failed to decrease the expression of neuropeptide Y in the hypothalamus and of glucose-6-phosphatase in the liver following short term overfeeding. The lack of hypothalamic responses to oleic acid following short term overfeeding is likely to contribute to the rapid onset of weight gain and hepatic insulin resistance in this animal model.