Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans.
Effects of beta-adrenergic blockade on ventilation and gas exchange during exercise in humans.
复制标题
β-肾上腺素能阻断对人类运动期间通气和气体交换的影响。
DOI：
10.1152/jappl.1983.54.5.1306
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Wasserman,K
中科院分区：
文献类型：
--
作者：
Petersen,ES;Whipp,BJ;Davis,JA;Huntsman,DJ;Brown,HV;Wasserman,K
在6名健康青年男性受试者中，研究了静脉注射盐酸普萘洛尔（0.2mg/kg）诱导的β-肾上腺素能阻滞剂对递增负荷或恒负荷运动时呼吸和气体交换反应的影响。运动时心率降低约20%，而心输出量，如通过Kim等的方法的改进（J.Appl.Physiol.21：1338-1344，1966）估计的，降低约15%。工作率和摄氧量（VO 2）之间的关系不受普萘洛尔，而最大摄氧量（VO 2 max）下降了5%，无氧阈值，估计非侵入性，降低了23%。CO2输出量（VCO 2）与潮气末CO2分压（PCO 2）、VCO 2与每分钟通气量（VE）的关系均未受影响。VO 2，VCO 2和VE在从空载踏板到中等（约100米）踏板的瞬态过程中变化的时间常数。50% VO 2 max）或重度（约67%VO2max）的工作率与先前报道的值一致，即，分别为42、60和69秒。β-阻滞剂与61 s的VO 2时间常数显著增加相关，但VCO 2和VE的变化不太一致且不显著。心率的时间常数从40秒增加到45秒，增加幅度很小，但很显著。可以得出结论，普萘洛尔发挥其主要影响在运动过程中对心血管系统没有任何明显的影响，对排泄控制。
The effects of beta-adrenergic blockade induced by intravenous propranolol hydrochloride (0.2 mg/kg) on ventilatory and gas exchange responses to exercise were studied during tests in which the work rate was either increased progressively or maintained at a constant load in six healthy young male subjects. Heart rate during exercise decreased by about 20% and cardiac output, as estimated by a modification of the method of Kim et al. (J. Appl. Physiol. 21: 1338–1344, 1966), by about 15%. The relation between work rate and O2 uptake (VO2) was unaffected by propranolol, whereas maximal O2 uptake (VO2max) decreased by 5% and the anaerobic threshold, estimated noninvasively, was lowered by 23%. The relations between CO2 output (VCO2) and end-tidal CO2 partial pressure (PCO2) and between VCO2 and minute ventilation (VE) were both unaffected. The time constants for changes of VO2, VCO2, and VE during on-transients from unloaded pedaling to either a moderate (ca. 50% VO2max) or a heavy (ca. 67% VO2max) work rate in the control studies were in agreement with previously reported values, i.e., 42, 60, and 69 s, respectively. beta-Blockade was associated with a significantly increased time constant for VO2 of 61 s but with less consistent and insignificant changes for VCO2 and VE. There was a small but significant increase of the time constant for heart rate from 40 to 45 s. It is concluded that propranolol exerts its primary influence during exercise on the cardiovascular system without any discernible effect on ventilatory control.