The role of the Nrf2/Keap1 signaling cascade in mechanobiology and bone health.
The role of the Nrf2/Keap1 signaling cascade in mechanobiology and bone health.
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DOI：
10.1016/j.bonr.2021.101149
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发表时间：
2021-12
期刊：
影响因子：
2.5
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Priddy C;Li J
随着现代医学的进步，骨骼健康正成为全球人口中日益普遍的问题，预期寿命不断增长。无数因素导致骨强度下降，而年龄几乎会加剧所有因素。骨质流失的有害影响对生活质量有着深远的影响。因此，非常需要充分探索可能提供抗衰老益处并增加骨组织的寿命和强度的潜在治疗靶点。Keap 1-Nrf 2通路是这一研究的一个很有前途的途径。该途径的细胞保护和抗氧化功能已被证明可以减轻氧化应激对骨组织的有害影响，但这种情况发生的确切细胞和分子机制尚未完全了解。目前，完善的动物和负荷模型允许以组织特异性或甚至细胞特异性方式探索Keap 1-Nrf 2通路的作用。此外，目前正在进行临床试验的Nrf 2激活剂可用于研究在这种细胞保护级联反应中起作用的特定细胞机制。尽管Nrf 2激活剂治疗的时机和剂量需要进一步研究，但这些激活剂在临床上用于预防和治疗骨质疏松症方面具有很大的潜力。
In conjunction with advancements in modern medicine, bone health is becoming an increasingly prevalent concern among a global population with an ever-growing life expectancy. Countless factors contribute to declining bone strength, and age exacerbates nearly all of them. The detrimental effects of bone loss have a profound impact on quality of life. As such, there is a great need for full exploration of potential therapeutic targets that may provide antiaging benefits and increase the life and strength of bone tissues. The Keap1-Nrf2 pathway is a promising avenue of this research. The cytoprotective and antioxidant functions of this pathway have been shown to mitigate the deleterious effects of oxidative stress on bone tissues, but the exact cellular and molecular mechanisms by which this occurs are not yet fully understood. Presently, refined animal and loading models are allowing exploration into the effect of the Keap1-Nrf2 pathway in a tissue-specific or even cell-specific manner. In addition, Nrf2 activators currently undergoing clinical trials can be utilized to investigate the particular cellular mechanisms at work in this cytoprotective cascade. Although the timing and dosing of treatment with Nrf2 activators need to be further investigated, these activators have great potential to be used clinically to prevent and treat osteoporosis.
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