Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor
Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor
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DOI：
10.2337/diabetes.52.11.2790
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发表时间：
2003-11-01
期刊：
影响因子：
7.7
通讯作者：
Saudek, CD
中科院分区：
文献类型：
--
作者：
Boyne, MS;Silver, DM;Saudek, CD
这项研究的目的是使用皮下连续血糖传感器来确定血糖和间质血糖动态的时间差。共有14名1型糖尿病患者每人在腹部皮下放置了两个传感器(美敦力/MiniMed CGMS)，每5分钟采集一次数据。每隔5分钟采一次血糖，共8次，同时给予2次流质餐。将一种平滑算法应用于血糖和间质血糖曲线。葡萄糖示踪的第一个导数定义并量化了上升、峰值、下降和最低点的时间。总共使用了24个数据集来分析每个患者的间质和血糖之间以及传感器之间的时间差。血糖和间质葡萄糖的时间差为4~10min，81%的患者间质血糖滞后于血糖(95%cis 72.5和89.5%)。每名患者两个传感器之间的平均(+/-SD)差为6.7+/-5.1分钟，代表传感器响应的随机变化。总之，无论血糖是上升还是下降，间质血糖都滞后于血糖，但在这个传感器系统中，传感器间的可变性是相当大的。间质和血糖动力学的比较必须考虑传感器之间的可变性。
The objective of this study was to use a subcutaneous continuous glucose sensor to determine time differences in the dynamics of blood glucose and interstitial glucose. A total of 14 patients with type 1 diabetes each had two sensors (Medtronic/MiniMed CGMS) placed subcutaneously in the abdomen, acquiring data every 5 min. Blood glucose was sampled every 5 min for 8 It, and two liquid meals were given. A smoothing algorithm was applied to the blood glucose and interstitial glucose curves. The first derivatives of the glucose traces defined and quantified the timing of rises, peaks, falls, and nadirs. Altogether, 24 datasets were used for the analysis of time differences between interstitial and blood glucose and between sensors in each patient. Time differences between blood and interstitial glucose ranged from 4 to 10 min, with the interstitial glucose lagging behind blood glucose in 81% of cases (95% CIs 72.5 and 89.5%). The mean (+/-SD) difference between the two sensors in each patient was 6.7 +/- 5.1 min, representing random variation in sensor response. In conclusion, there is a time lag of interstitial glucose behind blood glucose, regardless of whether glycemia is rising or falling, but intersensor variability is considerable in this sensor system. Comparisons of interstitial and blood glucose kinetics must take statistical account of variability between sensors.