ALLOIMMUNIZATION IN 2 MULTI-TRANSFUSED PATIENT POPULATIONS
ALLOIMMUNIZATION IN 2 MULTI-TRANSFUSED PATIENT POPULATIONS
复制标题
DOI：
10.1046/j.1537-2995.1981.21481276005.x
复制
发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
HOLLAND, PV
中科院分区：
文献类型：
--
作者：
COLES, SM;KLEIN, HG;HOLLAND, PV
进行了一项回顾性研究以确定 2 个多次输血患者群体的同种免疫频率。研究人员对两个有输血记录的患者群体进行了研究：157 名患者患有镰状细胞病 (SCD)，161 名患者患有地中海贫血。在 99 名输血的 SCD 患者中，有 23 名检测到了 44 种抗体。主要抗体为Rh组：17个为抗-rh"(E)，8个为抗-rh''(C)，4个为抗-rh''w(Cw)。其余抗体中，5个为抗Kell，3个为抗Jka，2个为抗Jkb，3个为抗Fya，1个为抗Bga，1个为抗S。在地中海贫血患者中，在 39 名输血患者中，有 4 名检测到 6 种抗体，分别有 2 名抗 Kell 抗体、1 名抗 Rho(D) 抗体、抗-rh''(C) 抗体、抗-rh''w(Cw) 抗体和抗 Fya 抗体。 2个人群中，同种免疫患者、输血患者的抗体总数和Rh抗体数量没有显着差异（P > 0.05）。
A retrospective study was undertaken to determine the frequency of alloimmunization in 2 multitransfused patient populations. Two patient populations whose transfusion records were available were studied: 157 patients had sickle cell disease (SCD) and 161 had thalassemia. Forty-four antibodies were detected in 23 of the 99 transfused SCD patients. The predominant antibodies were in the Rh group: 17 were anti-rh"(E), 8 were anti-rh''(C), and 4 were anti-rh''w(Cw). Of the remaining antibodies, 5 were anti-Kell, 3 were anti-Jka, 2 were anti-Jkb, 3 were anti-Fya, 1 was anti-Bga, and 1 was anti-S. In the thalassemic patients, 6 antibodies were detected in 4 of the 39 transfused patients. Of these, there were 2 anti-Kell and 1 anti-Rho(D), anti-rh''(C), anti-rh''w(Cw), and anti-Fya each. Although the SCD patients were more likely to have been transfused at the parent institution than were the thalassemic patients (69% vs. 24%, P < 0.05), the frequencies of alloimmunized patients, the total number of antibodies, and the number of Rh antibodies did not differ significantly (P > 0.05) for transfused patients in the 2 populations.