Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex
Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex
复制标题
DOI：
10.1016/j.fgb.2015.02.009
复制
发表时间：
2015-05-01
影响因子：
3
通讯作者：
Boekhout, Teun
中科院分区：
文献类型：
--
作者：
Hagen, Ferry;Khayhan, Kantarawee;Boekhout, Teun
系统发育分析的II遗传位点和许多基因分型研究的结果显示显着的遗传多样性与致病性隐球菌gattii/新型隐球菌物种复杂。系谱一致性，合并为基础的，和物种树的方法支持复杂的不同和一致的血统的存在。因此，我们建议认识到目前的C neoformans变种。Grubii和新生隐孢子虫C neoformans var. neoformans作为单独的种，和C gattii内的5种。C.新生儿CBS 132代表血清型AD杂合体并被替换。新界定的物种在致病性、患者群体的患病率以及生物化学和生理学方面（如对抗真菌药物的敏感性）存在差异。MALDI-TOF质谱法很容易区分新识别的物种。(C)2015作者爱思唯尔公司出版这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Phylogenetic analysis of II genetic loci and results from many genotyping studies revealed significant genetic diversity with the pathogenic Cryptococcus gattii/Cryptococcus neoformans species complex. Genealogical concordance, coalescence-based, and species tree approaches supported the presence of distinct and concordant lineages within the complex. Consequently, we propose to recognize the current C neoformans var. grubii and C neoformans var. neoformans as separate species, and five species within C gattii. The type strain of C. neoformans CBS132 represents a serotype AD hybrid and is replaced. The newly delimited species differ in aspects of pathogenicity, prevalence for patient groups, as well as biochemical and physiological aspects, such as susceptibility to antifungals. MALDI-TOF mass spectrometry readily distinguishes the newly recognized species. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).