Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer
Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer
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DOI：
10.1002/bjs.5706
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发表时间：
2007-08-01
影响因子：
9.6
通讯作者：
McMillan, D. C.
中科院分区：
文献类型：
--
作者：
Crozier, J. E. M.;Mckee, R. F.;McMillan, D. C.
背景资料：本研究的目的是评估术前和术后全身炎症反应和生存的患者接受潜在的根治性切除术结直肠cancer.Methods：180例结直肠癌患者进行了研究。结果：C反应蛋白（CRP）浓度峰值出现在术后第2天（P < 0.001）;在研究过程中，59名患者死亡，30人死于癌症，29人死于并发症。将第2天CRP浓度二分。在单变量分析中，先进的肿瘤淋巴结转移阶段（P = 0.002），提高术前CRP水平（P < 0.001）和低白蛋白血症（P = 0.043）的存在与较差的癌症特异性survival.Conclusion：术前，而不是术后CRP浓度与肿瘤特异性生存差的患者进行潜在的根治性切除结直肠癌。
Background: The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.Methods: One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C-reactive protein (CRP) were measured before surgery and in the immediate postoperative period.Results: The peak in CRP concentration occurred on day 2 (P < 0.001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0.002), a raised preoperative CRP level (P < 0.001) and the presence of hypoalbuminaemia (P = 0.043) were associated with poorer cancer-specific survival.Conclusion: Preoperative but not postoperative CRP concentrations are associated with poor tumour-specific survival in patients undergoing potentially curative resection for colorectal cancer.