Impaired emotional declarative memory following unilateral amygdala damage
Impaired emotional declarative memory following unilateral amygdala damage
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DOI：
10.1101/lm.7.3.180
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发表时间：
2000-05-01
影响因子：
2
通讯作者：
Denburg, N
中科院分区：
文献类型：
--
作者：
Adolphs, R;Tranel, D;Denburg, N
对双侧杏仁核损伤患者的案例研究和对正常人的功能成像研究表明，杏仁核在将情绪激发刺激编码为长期陈述性记忆中起着关键作用。然而，有几个问题仍然知之甚少：左杏仁核和右杏仁核的单独作用，杏仁核参与记忆巩固的时间过程，以及它帮助巩固的知识结构类型。我们调查了这些问题，在八个科目与单侧杏仁核损伤，使用几种不同的措施。为了比较，我们的主要任务使用相同的刺激，以前使用的调查情绪陈述性记忆患者双侧杏仁核损伤。与脑损伤组和正常对照组的对比显示，左侧杏仁核损伤的受试者对情感刺激的记忆受损，尽管对中性刺激的记忆完全正常（由于一些警告，右侧杏仁核损伤的受试者的研究结果不太清楚）。后续实验表明，情绪刺激对记忆的正常促进可能会在较长的时间内（>30分钟）发展，这与之前的研究结果一致，我们报告的具体损害可能部分取决于所使用任务的词汇性质（书面问卷）。我们强调记忆巩固的复杂性和时间上的延长性，并认为杏仁核可能会影响这一过程的特定组成部分。
Case studies of patients with bilateral amygdala damage and functional imaging studies of normal individuals have demonstrated that the amygdala plays a critical role in encoding emotionally arousing stimuli into long-term declarative memory. However, several issues remain poorly understood: the separate roles of left and right amygdala, the time course over which the amygdala participates in memory consolidation, and the type of knowledge structures it helps consolidate. We investigated these questions in eight subjects with unilateral amygdala damage, using several different measures. For comparison, our main task used stimuli identical to those used previously to investigate emotional declarative memory in patients with bilateral amygdala damage. Contrasts with both brain-damaged and normal control groups showed that subjects with left amygdala damage were impaired in their memory for emotional stimuli, despite entirely normal memory for neutral stimuli (because of a number of caveats, the findings from subjects with right amygdala damage were less clear). Follow-up experiments suggested that the normal facilitation of memory for emotional stimuli may develop over an extended time course (>30 min), consistent with prior findings, and that the specific impairment we report may depend in part on the lexical nature of the task used (written questionnaire). We stress the complex and temporally extended nature of memory consolidation and suggest that the amygdala may influence specific components of this process.