INTERLEUKIN-4 IS IMPORTANT IN PROTECTIVE IMMUNITY TO A GASTROINTESTINAL NEMATODE INFECTION IN MICE
INTERLEUKIN-4 IS IMPORTANT IN PROTECTIVE IMMUNITY TO A GASTROINTESTINAL NEMATODE INFECTION IN MICE
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DOI：
10.1073/pnas.88.13.5513
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发表时间：
1991-07-01
影响因子：
11.1
通讯作者：
FINKELMAN, FD
中科院分区：
文献类型：
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作者：
URBAN, JF;KATONA, IM;FINKELMAN, FD
寄生蠕虫通常诱导速发型超敏反应的成分，包括血清IgE升高、嗜酸性粒细胞增多和粘膜肥大细胞。这些反应是T细胞依赖性的，并与从致敏宿主中快速驱逐寄生蠕虫有关;现有的实验系统未能确定细胞因子在这些反应中的确切作用。我们在这里报告，抗白细胞介素4或抗白细胞介素4受体抗体阻断多克隆IgE反应的寄生线虫，Heligmosomoides polygyrus，并废除保护性免疫感染。相反，抗白细胞介素5抗体阻止H.多脑回诱导的嗜酸性粒细胞增多，但不阻止保护。这些数据提供的证据表明，一个特定的细胞因子影响寄生线虫在宿主中的生理和生存。
Parasitic helminths typically induce components of immediate-type hypersensitivity, including elevated serum IgE, eosinophilia, and mucosal mast cells. These responses are T-cell-dependent and associated with rapid expulsion of parasitic worms from a sensitized host; existing experimental systems have failed to define the precise role of cytokines in these responses. We report here that anti-interleukin 4 or anti-interleukin 4 receptor antibodies block the polyclonal IgE response to a parasitic nematode, Heligmosomoides polygyrus, and abrogate protective immunity to the infection. In contrast, anti-interleukin 5 antibody prevented H. polygyrus-induced eosinophilia but did not prevent protection. These data provide evidence that a specific cytokine affects the physiology and survival of a parasitic nematode in the host.