Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain
Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain
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DOI：
10.1111/j.1748-5827.2007.00344.x
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发表时间：
2007-08-01
影响因子：
1.6
通讯作者：
Jeffery, N. D.
中科院分区：
文献类型：
--
作者：
Rusbridge, C.;Carruthers, H.;Jeffery, N. D.
目的：这项研究的目的是测试的假设，疼痛与脊髓灰质炎的狗是依赖于大小和参与的背侧部分的spinal cord.METHODS：蒙面观察员确定脊髓空洞的尺寸和精确的位置在脊髓内的磁共振成像的55骑士查尔斯王猎犬与脊髓灰质炎。去除掩蔽后，空洞的大小和位置进行了比较队列的狗表现出疼痛与那些没有。结果：最大空洞宽度是最强的预测疼痛，抓挠行为和脊柱侧凸的狗脊髓灰质炎。疼痛和syrinx大小呈正相关，位于脊髓背侧的一半syrinxes的脊髓cord.Clinical Significance：大syrinxes与脊髓背侧部分的损伤与持续性疼痛，这表明这组患者的疼痛行为表示很可能是“神经性疼痛”，导致在受损的背角神经加工紊乱。因此，常规的止痛药物可能无效。
OBJECTIVES: This study was designed to test the hypothesis that pain associated with syringomyelia in dogs is dependent upon size and involvement of the dorsal part of the spinal cord.METHODS: Masked observers determined syrinx dimensions and precise location within the spinal cord on magnetic resonance images of 55 cavalier King Charles spaniels with syringomyelia. After removal of masking, syrinx size and location were compared between the cohorts of dogs that exhibited pain with those that did not.RESULTS: Maximum syrinx width was the strongest predictor of pain, scratching behaviour and scoliosis in dogs with syringomyelia. Both pain and syrinx size were positively correlated with syrinxes located in the dorsal half of the spinal cord.CLINICAL SIGNIFICANCE: Large syrinxes associated with damage to the dorsal part of the spinal cord are associated with persistent pain suggesting that the pain behaviour expressed by this group of patients is likely to be "neuropathic pain," resulting from disordered neural processing in the damaged dorsal horn. As such it is likely that conventional analgesic medication may be ineffective.