Elevated serum free IL-18 in neuropsychiatric systemic lupus erythematosus patients with seizure disorders
Elevated serum free IL-18 in neuropsychiatric systemic lupus erythematosus patients with seizure disorders
复制标题
伴有癫痫症的神经精神系统性红斑狼疮患者血清游离 IL-18 升高
DOI：
10.1177/09612033211069853
复制
发表时间：
2022-01-19
期刊：
影响因子：
2.6
通讯作者：
Yang, Min
中科院分区：
文献类型：
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作者：
Liang, Renge;Zheng, Lijuan;Yang, Min
背景由于IL-18和IL-18结合蛋白(IL-18BP)的异常调节可能参与系统性红斑狼疮(SLE)的发生并促进非自身免疫性癫痫的发生，本研究的目的是探讨IL-18和IL-18BP的相互作用在神经精神性系统性红斑狼疮相关癫痫发作中的作用。方法收集2020~2021年收治的137例SLE患者和30例健康体检者的临床资料。采用酶联免疫吸附试验检测所有患者和HC患者血清总IL-18和IL-18BP水平。根据质量作用定律计算游离IL-18。结果137例SLE患者中，活动性疾病103例，分为NPSLE组(n=50)和非NPSLE组(n=53)。在NPSLE患者中，16例有癫痫发作障碍。NPSLE患者血清游离IL-18水平升高(277.6[150.9~428.8]pg/mL)，且与疾病活动性呈正相关(r=0.268，p=0.002)。伴有惊厥障碍的NPSLE患者血清游离IL-18水平(350.9[237.9~455.9]pg/mL)显著高于有其他神经精神症状患者(237.7[124.6~428.8]pg/mL)。结论神经精神性系统性红斑狼疮(NPSLE)患者血清中游离IL-18的表达增加，尤其在NPSLE相关性癫痫患者中更为明显。活动期SLE患者血清游离IL-18水平显著升高。在这方面，游离IL-18可能参与了NPSLE相关癫痫的发病机制，并与疾病活动性有关。
Background Since dysregulation of total Interleukin (IL)-18 and IL-18 binding protein (IL-18BP) may participate in systemic lupus erythematosus (SLE) and contribute to the occurrence of non-autoimmune epilepsy, the aim of the current work is to investigate whether the interaction between IL-18 and IL-18BP plays any role in neuropsychiatric systemic lupus erythematosus related seizures. Methods Data from 137 SLE patients and 30 healthy controls (HC) were consecutively collected from 2020 to 2021. Serum levels of total IL-18 and IL-18BP for all patients and HC were measured by ELISA test. Free IL-18 was calculated based on the law of mass action. Results Among the 137 SLE patients, 103 had active disease and were classified into NPSLE (n = 50) and Non-NPSLE (n = 53) groups. Among the NPSLE patients, 16 had seizure disorders. Serum free IL-18 levels were increased in NPSLE (277.6 [150.9–428.8]pg/mL) and were correlated with disease activity (r = 0.268, p = 0.002). Moreover, serum free IL-18 levels in NPSLE patients with seizure disorders (350.9 [237.9–455.9]pg/mL) were significantly higher than the levels in those with other neuropsychiatric symptoms (237.7 [124.6–428.8] pg/mL). Conclusions The expression of free IL-18 was increased in neuropsychiatric systemic lupus erythematosus(NPSLE), especially in NPSLE related seizures. Also, serum levels of free IL-18 were significantly increased in active SLE patients. In this regard, free IL-18 may be involved in the pathogenesis of NPSLE related seizures and associated with disease activity.