Protein gradient films of fibroin and gelatine.
Protein gradient films of fibroin and gelatine.
复制标题
DOI：
10.1002/mabi.201300221
复制
发表时间：
2013-10
影响因子：
4.6
通讯作者：
Kai U. Claussen;Eileen S. Lintz;R. Giesa;H. Schmidt;T. Scheibel
中科院分区：
文献类型：
--
作者：
Kai U. Claussen;Eileen S. Lintz;R. Giesa;H. Schmidt;T. Scheibel
梯度是生物系统中的自然设计原则，用于减少不同机械性能材料连接时的应力集中。天然梯度材料的一个有趣的例子是足脂，它将贻贝固定在岩石和其他坚硬的基质上。在先前合成聚合物的研究基础上，受丝线的启发，用甘油塑化的明胶和丝素浇铸蛋白质梯度膜，表现出高度可重复性和光滑的机械梯度，其模量范围从160到550兆帕。生物相容性梯度膜的可重复生产是迈向医疗应用的第一步。
Gradients are a natural design principle in biological systems that are used to diminish stress concentration where materials of differing mechanical properties connect. An interesting example of a natural gradient material is byssus, which anchors mussels to rocks and other hard substrata. Building upon previous work with synthetic polymers and inspired by byssal threads, protein gradient films are cast using glycerine-plasticized gelatine and fibroin exhibiting a highly reproducible and smooth mechanical gradient, which encompasses a large range of modulus from 160 to 550 MPa. The reproducible production of biocompatible gradient films represents a first step towards medical applications.