INFLUENCE OF GLOBUS PALLIDUS ON ARM MOVEMENTS IN MONKEYS .2. EFFECTS OF STIMULATION
INFLUENCE OF GLOBUS PALLIDUS ON ARM MOVEMENTS IN MONKEYS .2. EFFECTS OF STIMULATION
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DOI：
10.1152/jn.1984.52.2.305
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发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
ANDERSON, ME
中科院分区：
文献类型：
--
作者：
HORAK, FB;ANDERSON, ME
在一项反应时间任务中，研究了脑白球（GP）内和周围的电刺激对基底神经节活动的影响。就像在苍白球发生kainic酸（KA）损伤后的情况一样（30），刺激改变了运动时间（MT），而不影响参与任务的肌肉的顺序激活模式，或者，在大多数情况下，反应时间（RT）。刺激苍白球内腹外侧段（GPi）或透镜带可减少运动次数，而刺激苍白球外段（GPe）、GPi背侧和壳核的许多部位可增加对侧手臂的运动次数。这些结果与假设一致，即当GPi的临界输出增加时，手臂运动加速，而当临界GPi输出减少时，手臂运动减慢，这可能是通过抑制过程（通过刺激诱导激活突触前GPi的抑制元件）或通过破坏GPi神经元（通过kainic酸）。讨论了基底神经节对肌电图（EMG）振幅的影响，而不是EMG激活的时空组织。
The effect of changing basal ganglia activity with electrical stimulation in and around the globus pallidus (GP) was studied in monkeys trained to make rapid arm-reaching movements to a visual target in a reaction time task. As was the case following kainic acid (KA) lesions of the globus pallidus (30), stimulation changed movement times (MT) without affecting the pattern of sequential activation of muscles involved in the tasks, or, in most cases, the reaction time (RT). Stimulation in the ventrolateral internal segment of the globus pallidus (GPi) or in the ansa lenticularis reduced movement times, whereas stimulation at many sites in the external pallidal segment (GPe), dorsal GPi, and putamen increased movement times for the contralateral arm. These results are consistent with the hypothesis that arm movements are speeded up when the critical output of GPi is increased and arm movements are slowed down when critical GPi output is reduced, either by an inhibitory process (via stimulation-induced activation of inhibitory elements presynaptic to GPi) or by destroying GPi neurons (via kainic acid). The influence of the basal ganglia on the scaling electromyographic (EMG) amplitude, as opposed to the spatiotemporal organization of EMG activation, is discussed.