Evidence for hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula
Evidence for hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula
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DOI：
10.1016/s0378-5955(03)00040-6
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发表时间：
2003-04-01
期刊：
影响因子：
2.8
通讯作者：
Marmo, F
中科院分区：
文献类型：
--
作者：
Avallone, B;Porritiello, M;Marmo, F
我们研究了未经治疗的动物和单次高剂量庆大霉素后的早期和后期时间间隔中蜥蜴壶腹嵴的毛细胞再生。研究采用s相标记物5-溴-2'-脱氧尿苷进行。我们的超微结构和免疫荧光研究表明，未经治疗的蜥蜴壶腹嵴中发生了细胞凋亡和毛细胞再生，并且在氨基糖苷类抗生素庆大霉素治疗后，再生过程大大加快。我们的观察表明，毛细胞再生与受损感觉上皮的修复密切相关，新的毛细胞似乎可能来自支持细胞。(C) 2003 Elsevier Science B.V.版权所有
We studied hair cell regeneration in the crista ampullaris of the lizard Podarcis sicula both in untreated animals and at early and late time intervals following a single high dose of gentamicim. The study was carried out using the S-phase marker 5-bromo-2'-deoxyuridine. Our ultrastructural and immunofluorescence studies showed that both apoptosis and hair cell regeneration happen in the lizard crista ampullaris in untreated animals, and that regenerative processes are greatly accelerated after treatment with the aminoglycoside antibiotic gentamicin. Our observations indicate that hair cell regeneration is strongly implicated in the repair of damaged sensory epithelium, and that new hair cells appear likely to arise from supporting cells. (C) 2003 Elsevier Science B.V. All rights reserved.