Follicular (nodular) lymphoma during the first two decades of life: a clinicopathologic study of 12 patients.
Follicular (nodular) lymphoma during the first two decades of life: a clinicopathologic study of 12 patients.
复制标题
生命前二十年的滤泡性（结节性）淋巴瘤：12 名患者的临床病理学研究。
DOI：
10.1002/1097-0142(19811115)48:10
复制
发表时间：
1981
期刊：
影响因子：
6.2
通讯作者：
Rappaport,H
中科院分区：
文献类型：
--
作者：
Winberg,CD;Nathwani,BN;Bearman,RM;Rappaport,H
研究人员对 12 名在生命的前 20 年内患上滤泡型非霍奇金淋巴瘤的患者进行了研究。 8 例为低分化淋巴细胞型；其余四个为“组织细胞”类型。 12 名患者中有 11 名是男性。九人无症状，八人头部和颈部有淋巴结肿大。年龄比较显示，儿科（<16 岁）患者（83%）的疾病程度倾向于局部（I 期和 II 期），而青少年（16-19 岁）患者（83%）的疾病程度则倾向于全身性。通常接受化疗和/或放疗的患者中有 8 名患者获得了持续 3-58 个月的完全缓解（中位时间为 17.5 个月）。其中五人仍处于缓解期；三个已经复发。 7 例自诊断后存活 12-120 个月（中位数为 48 个月）；六人没有疾病的临床证据。其余 5 名患者在诊断后 2 至 164 个月（中位时间 13 个月）死亡。死于淋巴瘤的四名患者中，有三名尸检显示患有弥漫性“组织细胞性”淋巴瘤。不良预后因素包括 1) 初始治疗后未能达到完全缓解； 2）结外疾病（累及脾脏和肝脏的低分化淋巴细胞型除外）； 3) 弥漫性“组织细胞性”淋巴瘤的发展。发生在生命第二个十年的滤泡性淋巴瘤具有与成人滤泡性淋巴瘤相似的生物学行为。
Twelve patients who developed non‐Hodgkin's lymphoma with a follicular pattern during the first two decades of life were studied. Eight had the poorly differentiated lymphocytic type; the remaining four had the “histiocytic” type. Eleven of the 12 patients were male. Nine were asymptomatic, and eight had lymphadenopathy in the head and neck region. Comparison of ages revealed the extent of disease tended to be localized (Stages I and II) in the pediatric (<16 years old) patients (83%) and generalized in the adolescent‐young adult (16–19 years old) patients (83%). Often patients treated with chemotherapy and/or radiotherapy, eight achieved complete remissions that lasted 3–58 months (median, 17.5 months). Five are still in remission; three have relapsed. Seven are alive 12–120 months from diagnosis (median, 48 months); six have no clinical evidence of disease. The remaining five patients died two to 164 months after diagnosis (median, 13 months). Three of the four patients who died with lymphoma had diffuse “histiocytic” lymphoma demonstrated at autopsy examination. Poor prognostic factors included 1) failure to achieve a complete remission following initial therapy; 2) extranodal disease (with the exception of the poorly differentiated lymphocytic type involving the spleen and liver); 3) development of diffuse “histiocytic” lymphoma. Follicular lymphoma occurring in the second decade of life has a biologic behavior similar to follicular lymphoma in adults.