Direct comparison of histology of microbleeds with postmortem MR images
Direct comparison of histology of microbleeds with postmortem MR images
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DOI：
10.1159/000139661
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Yamamoto, Toru
中科院分区：
文献类型：
--
作者：
Tatsumi, Shinsui;Shinohara, Miho;Yamamoto, Toru
背景：尽管梯度回波磁共振成像(GRE-MRI)中所谓的微出血(MBS)的临床意义已经得到了广泛的研究，但对组织病理学的评价明显不足。方法：对一例97岁高血压病患者9个生前MBS的水浸福尔马林固定组织块进行死后GRE-MRI检查。将组织学切片与MRI切片进行比较。结果：光镜检查发现左侧苍白球内8MB可见含铁血黄素的巨噬细胞簇，1MB可见小动脉假性钙化。5个病灶有高血压微血管病变。有含铁血黄素沉着的病灶大小与GRE-MRI的MBS大致相当。结论：除1例外，其余MBS均为含铁血黄素沉着，常与高血压微血管病变相关。版权所有(C)2008 S.Karger AG，巴塞尔。
Background: Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. Methods: Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensive woman with 9 antemortem MBs. Histologic slides were compared with those of MRI. Results: Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar pseudocalcification in 1 MB in the left pallidum. Hypertensive microangiopathies were found in 5 lesions. The sizes of the lesions with hemosiderin deposits were roughly comparable with the MBs of GRE-MRI. Conclusions: All of the MBs but for 1 exception were proved to be hemosiderin deposits and frequently associated with hypertensive microangiopathy. Copyright (C) 2008 S. Karger AG, Basel.