THE PERIOD GENE OF DROSOPHILA CARRIES SPECIES-SPECIFIC BEHAVIORAL INSTRUCTIONS
THE PERIOD GENE OF DROSOPHILA CARRIES SPECIES-SPECIFIC BEHAVIORAL INSTRUCTIONS
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DOI：
10.1002/j.1460-2075.1988.tb03280.x
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发表时间：
1988-12-01
期刊：
影响因子：
11.4
通讯作者：
ROSBASH, M
中科院分区：
文献类型：
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作者：
PETERSEN, G;HALL, JC;ROSBASH, M
本文分析比较了黑腹果蝇（Drosophilamelanogaster）和果蝇（D.伪暗D. pseudobscura的周期比D.黑腹果蝇我们还改造了D。黑腹果蝇携带含有D.假暗期基因。对含有该杂交基因的果蝇进行的行为学分析表明，D. pseudobscura per基因能够拯救节律性缺陷的mammic，pero1 D。黑腹菌更重要的是，有些菌株的节律比D. melanogaster（以及携带等价D. melanogaster per gene construct），因此与D.伪暗结果表明，每基因的一级氨基酸序列编码物种特异性的行为指令，当只有每基因转移到不同的物种是可检测的。
We have analyzed and compared the circadian locomotor activity rhythms of Drosophila melanogaster and D. pseudoobscura. The rhythms of D. pseudoobscura are stronger and the periods shorter than those of D. melanogaster. We have also transformed D. melanogaster flies with a hybrid gene containing the coding region of the D. pseudoobscura period (per) gene. Behavioral assays of flies containing this hybrid gene show that the per protein encoded by the D. pseudoobscura per gene is able to rescue the rhythmic deficiencies of arrhythmic, pero1 D. melalanogaster. More important, the rhythms of some of these strains are stronger and the periods shorter than those of D. melanogaster (and those of transformants which carry the equivalent D. melanogaster per gene construct) and hence resemble those of D. pseudoobscura. The results suggest that the primary amino acid sequence of the per gene encodes species-specific behavioral instructions that are detectable when only the per gene is transferred to a different species.