Reduced serologic response to Newcastle disease virus in broiler chickens exposed to a Chinese field strain of subgroup J avian leukosis virus
Reduced serologic response to Newcastle disease virus in broiler chickens exposed to a Chinese field strain of subgroup J avian leukosis virus
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DOI：
10.1637/7409-071305r1.1
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发表时间：
2006-06-01
期刊：
影响因子：
1.4
通讯作者：
Wang, Jianxin
中科院分区：
文献类型：
--
作者：
Cui, Zhizhong;Sun, Shuhong;Wang, Jianxin
本研究以1日龄SPF白色来亨鸡和商品代肉鸡为试验动物，研究了J亚群禽白血病病毒（ALV-J）中国野毒株NX 0101对免疫抑制作用的影响。结果表明，与SPF级白色来航鸡相比，NX 0101在早期感染商品代肉鸡的体重和免疫器官的重量下降更为显著。同时，对商品代肉鸡和SPF级白色来航鸡进行了免疫鸡群对纽卡斯尔病毒（NDV）和传染性法氏囊病病毒（IBDV）的抗体反应进行了评价和比较。与对照组鸡相比，接种NX 0101的商品代肉鸡对NDV疫苗的血凝抑制（HI）抗体应答早在接种后20天就显著降低。然而，当HI滴度在接种NX 0101和对照SPF白色来航鸡中达到峰值时，HI抗体应答没有显著差异，除了在感染的禽类中其下降得更快。这两种鸡对IBDV免疫的抗体应答均未出现明显下降。因此，我们得出结论，该ALV-J株NX 0101可以选择性地抑制新城疫病毒的体液免疫反应，特别是在肉鸡。但是没有进行攻击实验，因此，在这种情况下，不知道抗体水平的降低是否与对NDV的保护降低相关。
In this study, a Chinese field strain of subgroup J avian leukosis virus (ALV-J), NX0101, was studied for its immunosuppressive effects in both commercial broilers and SPF white Leghorn chickens infected at 1 day of age. Our data demonstrated that NX0101 induced much more significant body and immune organ weight loss in the infected commercial broiler chickens in an earlier age than that in the SPF white Leghorn chickens. At the same time antibody responses to vaccinations of Newcastle disease virus (NDV) and infectious bursa disease virus (IBDV) in the NX0101-infected chickens were also evaluated and compared between the commercial broiler chickens and the SPF white Leghorn chickens. Compared with the control group of chickens, the hemagglutination inhibition (HI) antibody response to NDV vaccines was significantly reduced in the NX0101-infected commercial broiler chickens from as early as 20 days after vaccination. However, no significant difference in HI antibody response was seen when HI titers reached their peaks in the NX0101-inoculated and control SPF white Leghorn chickens, except it declined significantly faster in infected birds. Neither of these two types of chickens showed significant decrease of antibody response to IBDV vaccination. Herein, we conclude that this NX0101 strain of ALV-J could selectively suppress humoral immune reactions to NDV, especially in broilers. But challenge experiments were not conducted and, therefore, it cannot be known if decreased antibody levels correlated with decreased protection against NDV in this case.