From preparation to online control: Reappraisal of neural circuitry mediating internally generated and externally guided actions
From preparation to online control: Reappraisal of neural circuitry mediating internally generated and externally guided actions
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DOI：
10.1016/j.neuroimage.2006.01.041
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发表时间：
2006-07-01
期刊：
影响因子：
5.7
通讯作者：
Rao, S. M.
中科院分区：
文献类型：
--
作者：
Elsinger, C. L.;Harrington, D. L.;Rao, S. M.
从记忆中内部产生的行动计划（IG）被认为是由辅助运动区（SMA）调节的，而使用感觉线索的在线外部指导计划（EG）被认为是由前运动皮层控制的。这一理论在一项与事件相关的功能磁共振成像研究中进行了研究，该研究将运动前和运动中的激活时间过程分开，以区分提前计划和在线控制。与流行的理论相反，SMA对于IG动作的在线控制并不重要。EG运动与IG运动的区别在于，在一个分布更广的右半球顶叶-额叶网络中，EG运动的激活程度比以前报道的要高。运动前和运动期间的比较表明，额纹状体网络是中央运动开始前准备行动。然而，与皮质和小脑区域不同，基底神经节在运动之前表现出与计划相关的活动，而不是在运动过程中。这些研究结果表明，基底神经节介导的规划和在线控制过程中以不同的方式，并建议在内部规划的行动序列，然后才实施纹状体的具体作用。(c)2006年爱思唯尔公司All rights reserved.
Action plans internally generated (IG) from memory are thought to be regulated by the supplementary motor area (SMA), whereas plans externally guided (EG) online using sensory cues are believed to be controlled by the premotor cortex. This theory was investigated in an event-related fMRI study that separated the time course of activation before and during movement to distinguish advance planning from online control. In contrast to prevailing theory, the SMA was not more important for online control of IG actions. EG movement was distinguished from IG movement by greater activation in a more distributed right hemisphere parietal-frontal network than previously reported. Comparisons between premovement and movement periods showed that frontostriatal networks are central for preparing actions before movement onset. However, unlike cortical and cerebellar regions, the basal ganglia exhibited plan ning-related activity before, but not during, movement. These findings indicate that the basal ganglia mediate planning and online control processes in different ways and suggest a specific role for the striatum in internally planning sequences of actions before they are implemented. (c) 2006 Elsevier Inc. All rights reserved.