Modulation of the natriuretic response to atrial natriuretic peptide by alterations in peritubular Starling forces in the rat.
Modulation of the natriuretic response to atrial natriuretic peptide by alterations in peritubular Starling forces in the rat.
复制标题
通过改变大鼠管周 Starling 力来调节对心房钠尿肽的利尿钠反应。
DOI：
10.1161/01.res.59.6.605
复制
发表时间：
1986
影响因子：
20.1
通讯作者：
Brenner,BM
中科院分区：
文献类型：
--
作者：
Mendez,RE;Dunn,BR;Troy,JL;Brenner,BM
心房利钠肽（ANP）输注后的利钠反应机制仍不完全明确。作为肾脏血管扩张剂，心房肽可以改变小管周围毛细血管物理力，有利于减少小管溶质重吸收。因此，我们研究了已知的肾内Starling力调节剂对麻醉大鼠静脉输注hANP[4-28]（0.5微克/千克/分钟）所致尿钠的影响。在第一个系列的研究中，与载药相比，ANP的输注导致明显的尿钠、利尿、菊粉清除率的增加和全身动脉压的轻微下降。血管紧张素II（0.1-0.2微克/千克/分钟静脉滴注）在ANP持续输注的基础上进一步升高肾灌注压，导致尿钠明显增强，与肾小球滤过率（GFR）的变化无关。在第二组实验中，高致瘤性交换输血使肾小球后毛细血管的致瘤压力升高，注射ANP没有导致尿钠，尽管GFR升高的幅度与注射ANP的等致瘤动物相同。这些观察结果与小管周围毛细血管水压和肿瘤压力调节ANP的利钠和利尿作用的观点一致。
The mechanisms underlying the natriuretic response to infusions of atrial natriuretic peptide (ANP) remain incompletely defined. By acting as renal vasodilators, atrial peptides may serve to alter peritubular capillary physical forces and favor a decrease in tubule solute reabsorption. Therefore, we studied the effects of known modifiers of intrarenal Starling forces on the natriuresis induced by infusion of intravenous hANP [4-28] (0.5 microgram/kg/min) in anesthetized, euvolemic Munich-Wistar rats. In the first series of studies, infusion of ANP resulted in a significant natriuresis, diuresis, and increase in inulin clearance and in a slight fall in systemic arterial pressure, as compared to vehicle infusion. Subsequent elevation of renal perfusion pressure by superimposition of angiotensin II infusion (0.1-0.2 microgram/kg/min i.v.) on continued ANP infusion resulted in marked further enhancement of natriuresis, independent of changes in glomerular filtration rate (GFR). In the second set of experiments, in which oncotic pressure in the postglomerular capillaries was elevated by hyperoncotic exchange transfusion, administration of ANP did not result in natriuresis, even though GFR increased by the same magnitude as that seen in isooncotic animals given ANP. These observations are consistent with the view that peritubular capillary hydraulic and oncotic pressures modulate the natriuretic and diuretic effects of ANP.