DENOVO DESIGN OF SEQUENCES FOR NUCLEIC-ACID STRUCTURAL-ENGINEERING
DENOVO DESIGN OF SEQUENCES FOR NUCLEIC-ACID STRUCTURAL-ENGINEERING
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DOI：
10.1080/07391102.1990.10507829
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发表时间：
1990-12-01
影响因子：
4.4
通讯作者：
SEEMAN, NC
中科院分区：
文献类型：
--
作者：
SEEMAN, NC
已经开发了一种交互式程序来分配用于核酸二级结构设计的序列。 该程序的主要目标是通过以方便的方式设计分支核酸单连接和寡连接结构来促进大分子结构研究。 所采用的序列对称性最小化算法的基本特征是将短序列视为词汇元素，其重复会减少对所得二级结构的控制。 这种方法的手动和半自动应用都是可用的。 通过应用该程序也可以设计线性核酸分子或含有单链环或连接器的分子。
An interactive procedure has been developed to assign sequences for the design of nucleic acid secondary structure. The primary goal of the procedure is to facilitate macromolecular architecture studies through the design of branched nucleic acid mono- and oligo-junction constructs in a convenient fashion. The essential feature of the sequence-symmetry minimization algorithm employed is the treatment of short sequences as vocabulary elements whose repetition decreases control over the resulting secondary structure. Both manual and semi-automatic application of this approach are available. The design of linear nucleic acid molecules or molecules containing single-stranded loops or connectors is also possible through application of the procedure.