Model organisms and target discovery.
Model organisms and target discovery.
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DOI：
10.1016/j.ddtec.2004.08.001
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发表时间：
2004-09-01
期刊：
影响因子：
--
通讯作者：
McKenna, Sean
中科院分区：
文献类型：
--
作者：
Muda, Marco;McKenna, Sean
从全基因组测序项目中获得的丰富信息并没有产生治疗干预的新靶点数量的平行增加。一些制药公司已经意识到，可以使用简单的模式生物来识别和验证新的药物靶标。经过几十年的基础研究实验室服务，酵母，蠕虫，苍蝇，鱼类和小鼠现在是现代药物发现计划的基石。
The wealth of information harvested from full genomic sequencing projects has not generated a parallel increase in the number of novel targets for therapeutic intervention. Several pharmaceutical companies have realized that novel drug targets can be identified and validated using simple model organisms. After decades of service in basic research laboratories, yeasts, worms, flies, fishes, and mice are now the cornerstones of modern drug discovery programs.: