Further studies on the chemistry of piperazic acids: New building blocks for beta-hydroxy-alpha-aminoacids through the aza-Achmatowicz reaction
Further studies on the chemistry of piperazic acids: New building blocks for beta-hydroxy-alpha-aminoacids through the aza-Achmatowicz reaction
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DOI：
10.1016/s0040-4039(97)01087-3
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发表时间：
1997-07-14
影响因子：
1.8
通讯作者：
Xi, N
中科院分区：
文献类型：
--
作者：
Ciufolini, MA;Shimizu, T;Xi, N
哌酸异常不愿进行N-2酰化似乎是由于电子效应，而不是空间/构象问题。一个适合探索这些问题的系统是通过方法组装的，该方法已经为相对立体化学和(L)或(D)构型的β -羟基- α -氨基酸产生了一个通用的构建块。1997爱思唯尔科学有限公司
The abnormal reluctance of piperazic acids to undergo N-2 acylation seems to be due to an electronic effect, not a steric/conformational problem. A system suitable for probing these issues was assembled by methods that have produced a versatile building block for beta-hydroxy-alpha-aminoacids of either relative stereochemistry and of either (L) or (D) configuration. (C) 1997 Elsevier Science Ltd.