Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
Small molecule inhibitors of type III secretion in Yersinia block the Chlamydia pneumoniae infection cycle
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DOI：
10.1016/j.febslet.2007.01.013
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发表时间：
2007-02-20
期刊：
影响因子：
3.5
通讯作者：
Bergstrom, Sven
中科院分区：
文献类型：
--
作者：
Bailey, Leslie;Gylfe, Asa;Bergstrom, Sven
衣原体目的细胞内寄生是一个复杂的过程，涉及代谢不活跃颗粒的传播，这些颗粒在宿主细胞内分化、复制和再分化。三型分泌系统（T3SS）在此过程中起作用。我们在此鉴定了一类水杨醛酰腙化学小分子，它们能特异性阻断衣原体的T3SS。这些化合物还影响发育周期，表明T3SS在衣原体的发病机制中具有关键作用。我们的研究结果为开发新型抗衣原体药物提供了一条此前未探索过的途径。（c）2007欧洲生物化学学会联合会。由爱思唯尔出版集团出版。保留所有权利。
Intracellular parasitism by Chlainydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated. p in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaidehydes that specifically blocks the T3S of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlaniydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.