Oral diseases - From detection to diagnostics
Oral diseases - From detection to diagnostics
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DOI：
10.1196/annals.1384.040
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Amerongen, Arte v. Nieuw
中科院分区：
文献类型：
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作者：
Ligtenberg, Antoon J. M.;de Soet, Johannes J.;Amerongen, Arte v. Nieuw
除了唾液，其他口腔成分，如牙龈沟液、上皮细胞、细菌、呼吸和牙菌斑都具有诊断潜力。对于口腔疾病，如龋齿和牙周病，目视诊断通常是足够的，但需要具有预测价值的客观诊断测试。因此，已经开发了像龋齿图这样的预测模型，该模型还包括口腔方面，如唾液分泌、缓冲能力和变形链球菌计数，用于预测龋齿。关于唾液成分和龋齿的相关性研究尚未得出结论，但关于功能方面的相关性研究，如唾液诱导的细菌聚集和龋齿，看起来很有希望。现代蛋白质组学技术使得同时研究参与这些功能的许多唾液成分成为可能。
In addition to saliva, other oral components such as gingival crevicular fluid, epithelial cells, bacteria, breath, and dental plaque have diagnostic potential. For oral diseases such as caries and periodontal disease, visual diagnosis is usually adequate, but objective diagnostic tests with predictive value are desired. Therefore, prediction models like the Cariogram have been developed that also include oral aspects such as saliva secretion, buffering capacity, and Streptococcus mutans counts for the prediction of caries. Correlation studies on salivary components and caries have not been conclusive, but correlation studies on functional aspects, such as saliva-induced bacterial aggregation and caries, look promising. Modern proteomic techniques make it possible to study simultaneously the many salivary components involved in these functions.