Toward a multiscale model of antigen presentation in immunity.
Toward a multiscale model of antigen presentation in immunity.
复制标题
免疫中抗原呈递的多尺度模型。
DOI：
10.1111/j.1600-065x.2007.00490.x
复制
发表时间：
2007
影响因子：
8.7
通讯作者：
Linderman,JenniferJ
中科院分区：
文献类型：
--
作者：
Kirschner,DeniseE;Chang,StewartT;Riggs,ThomasW;Perry,Nicolas;Linderman,JenniferJ
正常运作的免疫系统，特别是抗原呈递的过程，包括在多个长度和时间尺度上发生的事件。尽管生物学文献中有大量关于这些标度的信息，但没有一个单一的表示法将这些信息合成到总体免疫反应的模型中，因为它依赖于抗原提呈。在这篇文章中，我们概述了一种方法，用于整合相关生物和时间尺度上的信息，以生成主要组织相容性复合体II类介导的抗原递呈的这样一个表示。此外，我们开始讨论如何使用这些模型来回答有关感染机制以及新的治疗和疫苗策略的问题。
A functioning immune system and the process of antigen presentation in particular encompass events that occur at multiple length and time scales. Despite a wealth of information in the biological literature regarding each of these scales, no single representation synthesizing this information into a model of the overall immune response as it depends on antigen presentation is available. In this article, we outline an approach for integrating information over relevant biological and temporal scales to generate such a representation for major histocompatibility complex class II‐mediated antigen presentation. In addition, we begin to address how such models can be used to answer questions about mechanisms of infection and new strategies for treatment and vaccines.